Disproven

secondary progressive MS · Integrin blockade (lymphocyte trafficking)

Placebo-controlled phase 3 trials missed their main goal, and none succeeded. This applies to this patient group only.

Trials
1
Running now
0
Controlled phase 2/3 trials
1
People in controlled trials
889

Deciding trials (phase 3): 0 met, 1 did not.

Other linked trials: 0

Dose comparisons, trials against another medicine, add-on trials, phase 1 and uncontrolled studies. They are listed below but do not set the status.

Trials

  • ASCEND in SPMSdecides the statusStopped: not working

    Phase 3 · 2011 · Placebo-controlled · MSFT-NCT01416181

The deciding phase and counts come from the Trial Bank’s fixed rules.

Lab evidence

Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.

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History

  • 2026-10-28First listed as Disproven

Related hypotheses

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