2 November 2026

OCTOPUS (PLATYPUS in Australia)

  • Medicines: metformin, thioctic acid
  • Approach: Mitochondrial / oxidative stress
  • Area: Nerve and brain biology
  • Curation note: Interim stage-1 analysis (Sep 2026): alpha-lipoic acid continues to stage 2; metformin arm discontinued

Registry redacts arm drugs. First two arms named publicly as metformin and R/S alpha-lipoic acid.

Mechanism node assigned from the named arm drugs.

Interim result. Not a final efficacy result.

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