Confirmed
One controlled phase 3 trial met its main goal, and satralizumab is approved for this use.
IL-6 pathway: prevent attacks in NMOSD
Trial timeline
Trial start year. Dot size reflects participants where reported. Only trials that count towards the status are shown.
NMOSD · IL-6 pathway
Two or more controlled phase 3 trials met their main goal, or one did and a medicine of this approach is approved for this use.
- Trials
- 6
- Running now
- 1
- Controlled phase 2/3 trials
- 3
- People in controlled trials
- 298
Deciding trials (phase 3): 1 met, 0 did not.
Other linked trials: 5
Dose comparisons, trials against another medicine, add-on trials, phase 1 and uncontrolled studies. They are listed below but do not set the status.
Trials
- Efficacy and Safety Study of Satralizumab (SA237) as Monotherapy to Treat Participants With Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD)decides the statusMet main goal
Phase 3 · 2014 · Placebo-controlled · MSFT-NCT02073279
- Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to Treat Participants With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD)decides the statusMet main goal
Phase 3 · 2014 · Placebo-controlled · MSFT-NCT02028884
Phase 2/3 · 2017 · Compared with azathioprine · MSFT-NCT03350633
Eight (14%) of 59 patients in the tocilizumab group and 28 (47%) of 59 patients in the azathioprine group had a relapse at the end of the study (hazard ratio [HR] 0·236 [95% CI 0·107-0·518]; p<0·0001).
Read by software from the paper's abstract
Other linked trials: 5
These linked trials do not set the status.
- BEST-NMOSDOngoing
Phase 4 · 2026 · Not randomised
- SAkuraBonsaiStopped, other reason
Phase 4 · 2022 · Not randomised
Phase 1/2 · 2017 · Not randomised
The deciding phase and counts come from the Trial Bank’s fixed rules.
Lab evidence
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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History
- 2026-10-28Status changed from Being tested to Confirmed
- 2026-10-27First listed as Being tested
Related hypotheses
Assembled by software from public sources and not checked by people. Each record links to its source. Report an error