Confirmed
Two or more controlled phase 3 trials met their main goal.
Interferon beta: reduce relapses and new lesions in relapsing MS
Trial timeline
Trial start year. Dot size reflects participants where reported. Only trials that count towards the status are shown.
relapsing MS · Interferon beta
Two or more controlled phase 3 trials met their main goal, or one did and a medicine of this approach is approved for this use.
2 trial(s) stopped for safety reasons.
- Trials
- 32
- Running now
- 2
- Controlled phase 2/3 trials
- 5
- People in controlled trials
- 1916
Deciding trials (phase 3): 2 met, 0 did not.
Other linked trials: 30
Dose comparisons, trials against another medicine, add-on trials, phase 1 and uncontrolled studies. They are listed below but do not set the status.
Trials
- Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and Peginterferon Beta-1a (Plegridy) for the Treatment of Relapsing-Remitting Multiple Sclerosis in Pediatric Participantsdecides the statusStopped: safety
Phase 3 · 2019 · Placebo-controlled · MSFT-NCT03870763
Phase 3 · 2009 · Placebo-controlled · MSFT-NCT00906399
Phase 3 · 2006 · Placebo-controlled · MSFT-NCT00441103
Other linked trials: 30
These linked trials do not set the status.
- Full RespondersStopped, other reason
Phase 4 · 2022 · Not randomised
- PROCEEDNo result found
Phase 4 · 2014 · Not randomised
- Natalizumab De-escalation to Interferon-beta-1b in Patients With Relapsing-remitting Multiple SclerosisStopped, other reason
Phase 4 · 2012 · Not randomised
- Natalizumab De-escalation With Interferon Beta-1bNo result found
Phase 4 · 2010 · Compared with natalizumab
- SIMCOMBINResult in a paper, not read yet
Phase 4 · 2006 · Placebo-controlled
Phase 4 · 2004 · Compared with glatiramer acetate
- Safety and Efficacy Study of Doxycycline in Combination With Interferon-B-1a to Treat Multiple SclerosisNo result found
Phase 4 · 2003 · Not randomised
- ABOVENo result found
Phase 4 · 2003 · Compared with interferon beta-1b
- BECOMEMet main goal
Phase 4 · 2003 · Not randomised
- TWINSOngoing
Phase 3 · 2025 · Not randomised
The deciding phase and counts come from the Trial Bank’s fixed rules.
Lab evidence
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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History
- 2026-10-28Status changed from Being tested to Confirmed
- 2026-10-28Trials: 31 → 32
- 2026-10-28Status changed from Confirmed to Being tested
- 2026-10-27First listed as Confirmed
Related hypotheses
- Interferon beta: reduce relapses and new lesions in early MS (CIS or RIS)
- Interferon beta: reduce relapses and new lesions in relapsing and progressive MS
- Interferon beta: reduce relapses and new lesions in secondary progressive MS
- Interferon beta: reduce relapses and new lesions in MS (type not specified)
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