Ponesimod
How it works: Keeping immune cells out of the brain →
Ponvory
EU: Approved in the EU since 2021US: FDA approved 2021
- Molecule type
- Small molecule
- Mechanism (ChEMBL)
- Sphingosine 1-phosphate receptor Edg-1 agonist
- Targets
- Sphingosine 1-phosphate receptor 1
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
430 reports in total, 158 marked serious.
- Product dose omission issue75
- Fatigue35
- Dizziness24
- Dyspnoea23
- Headache22
- Product use issue17
- Nausea14
- Covid-1913
- Drug ineffective13
- Pain12
Trials
Key trials
Large trials with a reported result on their main goal.
- OPTIMUM
Completed · Phase 3 · Relapsing and progressive · Main goal met
Running now
- PIONEER
Ongoing · Phase 3 · Relapsing MS · ongoing
- Alemtuzumab
Running, not recruiting · Relapsing MS · ongoing
Other trials (6)
Completed small trials, dose-finding studies and trials in other diseases.
- OPTIMUM-LT
Completed · Phase 3 · Relapsing and progressive · results_posted_no_test
- POINT
Terminated · Phase 3 · Relapsing and progressive · stopped_other
- POINT
Terminated · Phase 3 · Relapsing MS
- Ponesimod, phase 2
Completed · Phase 2 · Relapsing MS · results_posted_no_test
- Ponesimod, phase 2
Completed · Phase 2 · Relapsing MS · Main goal met
- Ponesimod, phase 2
Completed · Phase 2 · Relapsing MS
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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