Alemtuzumab
How it works: Resetting the immune system →
Lemtrada
EU: Approved in the EU since 2013US: FDA approved 2001
FDA dates refer to the first approval of the product's licence. For alemtuzumab and ofatumumab this was an earlier cancer approval.
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- CAMPATH-1 antigen inhibitor
- Targets
- CAMPATH-1 antigen
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
- EMA referral (safety) · 2019-04-11
Lemtrada Source
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
19,415 reports in total, 16,715 marked serious.
- Headache1,897
- Fatigue1,870
- Pyrexia1,791
- Off label use1,678
- Rash1,197
- Nausea1,188
- Drug ineffective1,022
- Dyspnoea992
- Asthenia942
- Multiple sclerosis relapse911
Trials
Key trials
Large trials with a reported result on their main goal.
- CARE-MS II
Completed · Phase 3 · Relapsing MS · Main goal met
- CARE-MS I
Completed · Phase 3 · Relapsing MS · Main goal met
Running now
- Alemtuzumab
Running, not recruiting · Relapsing MS · ongoing
- DELIVER-MS
Running, not recruiting · Phase 4 · Relapsing MS · ongoing
Other trials (27)
Completed small trials, dose-finding studies and trials in other diseases.
- Alemtuzumab
Completed · Relapsing MS · no_result_found
- SUPPRESS
Completed · Phase 4 · Relapsing MS · results_posted_no_test
- LemKids
Terminated · Phase 3 · Relapsing MS · stopped_other
- Alemtuzumab
Terminated · Relapsing MS · stopped_other
- Alemtuzumab
Completed · MS (type not specified) · result_in_paper_unread
- ProgramMS
Status unknown · MS (type not specified) · result_in_paper_unread
- Alemtuzumab
Status unknown · Relapsing MS · no_result_found
- Alemtuzumab
Completed · MS (type not specified) · no_result_found
- LemCourse
Completed · Phase 3 · Relapsing MS · no_result_found
- SCALA
Completed · Phase 1 · Progressive MS · result_in_paper_unread
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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