Eculizumab
How it works: Medicines for NMOSD and MOGAD →
Soliris
EU: Approved in the EU since 2007US: FDA approved 2007
- Other names
- eculizumab-aagh, eculizumab-aeeb
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- Complement C5 inhibitor
- Targets
- Complement C5
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
54,063 reports in total, 32,360 marked serious.
- Fatigue5,894
- Off label use4,757
- Haemoglobin decreased3,929
- Headache3,486
- Death2,728
- Pyrexia2,425
- Dyspnoea2,191
- Asthenia2,035
- Nausea1,992
- Drug ineffective1,938
Trials
Running now
- BEST-NMOSD
Recruiting · Phase 4 · NMOSD · ongoing
- Eculizumab, phase 4
Recruiting · Phase 4 · NMOSD · ongoing
- EASE-NMO
Running, not recruiting · Phase 2 · NMOSD · ongoing
- Eculizumab, phase 3
Running, not recruiting · Phase 3 · NMOSD · ongoing
Other trials (5)
Completed small trials, dose-finding studies and trials in other diseases.
- EASE-NMO
Withdrawn · Phase 2 · NMOSD · stopped_other
- Eculizumab, phase 2 / phase 3
Terminated · Phase 2 / Phase 3 · NMOSD · stopped_other
- Eculizumab, phase 3
Completed · Phase 3 · NMOSD · results_posted_no_test
- PREVENT
Terminated · Phase 3 · NMOSD · stopped_other
- Eculizumab, phase 1 / phase 2
Completed · Phase 1 / Phase 2 · NMOSD · Main goal met
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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