Inebilizumab
How it works: Removing B cells →
Uplizna
EU: Approved in the EU since 2022US: FDA approved 2020
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- B-lymphocyte antigen CD19 binding agent
- Targets
- B-lymphocyte antigen CD19
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
113 reports in total, 102 marked serious.
- Off label use34
- Neuromyelitis optica spectrum disorder33
- Urinary tract infection11
- Pneumocystis jirovecii pneumonia9
- Infection8
- Pneumonia8
- Infusion related reaction7
- Pyrexia7
- Upper respiratory tract infection6
- Anaemia5
Trials
Key trials
Large trials with a reported result on their main goal.
- Inebilizumab, phase 2 / phase 3
Completed · Phase 2 / Phase 3 · NMOSD · Main goal met
Running now
- Inebilizumab
Recruiting · NMOSD · ongoing
- BEST-NMOSD
Recruiting · Phase 4 · NMOSD · ongoing
- Inebilizumab, phase 3
Not yet recruiting · Phase 3 · NMOSD · ongoing
- Inebilizumab, not applicable
Not yet recruiting · Not a drug-phase study · NMOSD · ongoing
- Inebilizumab, phase 4
Running, not recruiting · Phase 4 · NMOSD · ongoing
- Inebilizumab, phase 2
Recruiting · Phase 2 · NMOSD · ongoing
Other trials (5)
Completed small trials, dose-finding studies and trials in other diseases.
- Inebilizumab
Status unknown · NMOSD · no_result_found
- Inebilizumab, phase 4
Status unknown · Phase 4 · NMOSD · no_result_found
- Inebilizumab
Status unknown · NMOSD · no_result_found
- Inebilizumab, phase 2
Moved to EU CTIS registry · Phase 2 · NMOSD
- Inebilizumab, phase 1
Completed · Phase 1 · Relapsing and progressive · results_posted_no_test
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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