Trial on the effectiveness of Fampridine medication for upper limb function in people with MS.
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Dalfampridine
Voltage-gated potassium channel blocker
What it measured
Main measures
An upper limb responder to fampridine will be defined as a patient with both of the two “on treatment” 9-HPT assessments (assessments 4 & 5 or 7 & 8) improving 20% from the average of the baseline assessments (1, 2 & 3).
Arm and hand function
Other measures (1)
a) A secondary measure of upper limb responsiveness will be defined as a 20% improvement in from baseline in the average time taken to complete all seven tasks on the JTT “on treatment” (assessments 4 & 5 or 7 & 8) compared with baseline assessments (assessments 1,2 & 3).
Arm and hand function
Who could take part
Progressive MS
Inclusion: Patients with SPMS or PPMS, aged 18-70, who have Kurtzke EDSS scores in the range 4.0 to 7.0 inclusive and a walking speed with or without aids in the T25FW of 8.0 to 14.0 seconds and evidence of significant upper limb dysfunction as defined by a 9HPT of 15 – 90 seconds (dominant or non-dominant hand), will be recruited. Exclusion: 1) Patients with a history of seizures, significant liver dysfunction, significant renal dysfunction, significant upper or lower limb arthritis or any other disorder including cognitive dysfunction which would affect the ability to accurately complete questionnaires and give full informed consent.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
To assess the effect of treatment with fampridine in patients with secondary progressive MS (SPMS) or primary progressive MS (PPMS) with upper limb dysfunction (as defined by a 9-HPT time of between 15-90 seconds) and Kurtzke EDSS scores in the range 4.0-7.0 on
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History
Started
Feb 2012
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