The effect of medical cannabis on neuropathic pain and spasticity in patients with MS and SCI
What it found
The main measure did not show a significant benefit.
“Nevertheless, in this four-arm parallel trial, no effect was found between placebo and active treatment with THC or CBD alone or in combination on NP or spasticity in patients with either MS or SCI.”Read by software from the paper's abstract
| Group | n | Value |
|---|---|---|
| THC | 32 | pain 0.42 (-0.54-1.38); spasticity 0.24 (-0.67-1.45) |
| CBD | 31 | pain 0.45 (-0.47-1.38); spasticity 0.46 (-0.74-1.65) |
| THC&CBD | 31 | pain 0.16 (-0.75-1.08); spasticity 0.10 (-1.18-1.39) |
Total participants: 134
Read by software from the paper's abstract
What was tested
Treatment tested
- Cannabidiol
Cannabinoid CB1 receptor negative allosteric modulator
- Dronabinol
Cannabinoid CB1 receptor agonist
What it measured
Main measures
1) Mean pain intensity during the last week of active treatment compared with baseline (Diary, Numeric Rating Scale (NRS)).
Pain
Other measures (1)
1) Patient Global Impression of Change (PGIC)
Who could take part
MS (type not specified)
Inclusion: 1) Probable or definite neuropathic pain in more than three months with a mean baseline pain intensity NRS >3 and < 9 and/or spasticity severity NRS > 3. Exclusion: 1) Other pain conditions (e.g. diabetic neuropathy), which cannot be distinguished from central pain in MS and/or SCI
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
To evaluate the efficacy of the cannabinoids THC, CBD and a combination of CBD/THC on central neuropathic pain and spasticity in patients with multiple sclerosis and in patients with spinal cord injury
Papers
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History
Started
Jul 2018
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