MS_SV2

Treatment tested

• [18F]UCB-H

Other measures (1)

Inclusion: Participants, selected at the specialized MS outpatient clinic of the CHU of Liège, consist of patients with a diagnosis of RRMS according to Mc Donald criteria 2017, with no evidence of clinical progression. In order to eschew interference of recurrent relapses, patients have to be relapse-free for at least 6 months at the time of inclusion. Other inclusion criteria include: Exclusion: - Presence or history of neurological diseases other than MS, psychiatry diseases, major traumatic brain injury, major surgery , uncontrolled infection or medical condition, Female patient without contraception, physical or behavioural state incompatible with the current protocol (including MR compatibility, pregnancy, tutorship or guardianship.

The primary aim of the study is to assess regional brain synaptic density in MS patients of various duration and to determine whether a significant regional decrease in synaptic density can be detected, at the individual level, in comparison to age-matched healthy participants, using PET scanning and [18F]-UCB-H.