Fatigue Treatment Using Provigil

Treatment tested

• Modafinil

  Dopamine transporter inhibitor

Other measures (1)

Inclusion Criteria: * The patients should be diagnosed with clinically definite MS (Posner criteria). * EDSS at screening: 0 to 5.5, inclusive. * Positive Fatigue impact scale 40 points or more. * Age 18-55 years. * Co-operating patient, capable of complying with all of trial procedures (i.e. FIS, QOL, etc…). * Patient who signed written informed consent. * Women of childbearing potential must use effective birth control method during study. Exclusion Criteria: * Life threatening and/or unstable clinical condition which in the opinion of the investigator might compromise trial completion * A relapse during the last 30 days prior to the study. * Systemic steroid therapy within 30 days * Known hypersensitivity or intolerance, to Provigil or related substances or to any component of the formulation. * Sleep apnea * Narcolepsy * Participation in experimental drug trials during the last 30 days prior to the trial.

To determine whether therapy with Modafinal(Provigil) is safe and effective in fatigue in MS Patients