Locomotor Training in Persons With Multiple Sclerosis
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- Lokomat
Compared with
- resistive training
Results by group
Walking Speed as Assessed by 25' Timed Walk
at beginning,mid point, end and 12 weeks after intervention
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Lokomat Training Using Body Weight Support on a Treadmill | 22.7 seconds | 17.6 (Standard Deviation) | 17 |
| Resistive Training | 10.6 seconds | 4.9 (Standard Deviation) | 19 |
| Lokomat Training Using Body Weight Support on a Treadmill | 23.9 seconds | 20.9 (Standard Deviation) | 17 |
| Resistive Training | 9.8 seconds | 4.3 (Standard Deviation) | 19 |
| Lokomat Training Using Body Weight Support on a Treadmill | 19.4 seconds | 15.2 (Standard Deviation) | 17 |
| Resistive Training | 9.6 seconds | 3.7 (Standard Deviation) | 19 |
| Lokomat Training Using Body Weight Support on a Treadmill | 21.7 seconds | 16.7 (Standard Deviation) | 17 |
| Resistive Training | 10.5 seconds | 4.3 (Standard Deviation) | 19 |
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Lokomat Training Using Body Weight Support on a Treadmill | 17 | 0 (0.0%) | |
| Resistive Training | 19 | 0 (0.0%) |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Walking Speed as Assessed by 25' Timed Walk
at beginning,mid point, end and 12 weeks after intervention
Walking and mobility
Other measures (3)
Distance
baseline, mid point, end and 12 weeks after training
Walking and mobilityFatigue
baseline, mid, completetion, 3 months post
Thinking and memoryFatiguePASAT
baseline, mid, completion, 3 months post training
Thinking and memory
Who could take part
Progressive MS · 18 to 65
Inclusion Criteria: * Persons with Secondary progressive or Primary Progressive Multiple Sclerosis who are ambulatory with difficulty and /or assistive device Exclusion Criteria: * Ataxia * Unable to ambulate * Within 3 months of exacerbation
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Locomotor training is a new exercise modality that emphasizes task specificity to promote learning and neural plasticity. It has been reported to improve walking in patients with stroke, spinal cord injury and cerebral palsy. In this study, 40 patients with impaired ambulation due to Multiple Sclerosis will be randomized to receive 36 sessions of either locomotor training or an standard resistive exercise intervention.The locomotor training will be accomplished via a robotic device, the Lokomat, which will move the patient's legs on a treadmill while they are suspended in a harness.
Papers
Loading reviews and guidelines…
History
Started
Jul 2006
Main results due
Aug 2009
Finished
Aug 2009
Results posted
Aug 2016
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