Improving Hand Use in Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- CI Therapy
- CAM treatments
What it measured
Main measures
Motor Activity Log (MAL)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
Arm and hand function
Other measures (8)
Wolf Motor Function Test (WMFT)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
MSFC (Multiple Sclerosis Composite Measure)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
Disability progressionThinking and memoryWalking and mobilityArm and hand functionSARA (Scale for the Assessment and Rating of Ataxia)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
Physical functionEDSS (Expanded Disability Status Scale)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
Disability progressionFatigue Severity Scale (FSS)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
FatigueMSIS-29 (Multiple Sclerosis Impact Scale)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
Quality of life (reported by participants)MSSS-88 (Multiple Sclerosis Spasticity Scale)
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
SpasticityBaecke Activity Questionnaire
Before treatment, and immediately, 6 months, and 12 months after the end of treatment.
Who could take part
Relapsing and progressive · 21 to 80
Inclusion Criteria: * diagnosis of non-relapsing multiple sclerosis (primary progressive MS, secondary progressive MS) * reduced use of one of the hands because of MS * ability to pick up and release a small object with the more-affected hand when requested * can travel to the treatment program at the University of Alabama at Birmingham (UAB) * can undergo treatment for 2 weeks (Monday-Friday), 3.5 hours per day * can undergo MRI scan * any kind of medication used for MS is allowed except spasticity medicine Exclusion Criteria: * disease relapse in the past 3 months * pregnancy * marked pain with arm movement * severe uncontrolled medical illness * simultaneous treatment with another form of physical therapy
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study will compare two different kinds of physical therapy to improve use of the hands in individuals with multiple sclerosis (MS). One treatment will be Constraint-Induced Movement therapy (CI therapy), the other will be a set of Complementary and Alternative Medicine (CAM) treatments (yoga, relaxation exercises, aquatherapy, massage). The study will determine which of the two forms of treatment is more successful for improving hand use.
Papers
Results
Phase II Randomized Controlled Trial of Constraint-Induced Movement Therapy in Multiple Sclerosis. Part 2: Effect on White Matter Integrity.Neurorehabil Neural Repair · 2018
Results
Phase II Randomized Controlled Trial of Constraint-Induced Movement Therapy in Multiple Sclerosis. Part 1: Effects on Real-World Function.Neurorehabil Neural Repair · 2018
Background
Mark VW, Taub E, Bashir K, Uswatte G, Delgado A, Bowman MH, Bryson CC, McKay S, Cutter GR. Constraint-Induced Movement therapy can improve hemiparetic progressive multiple sclerosis. Preliminary findings. Mult Scler. 2008 Aug;14(7):992-4. doi: 10.1177/1352458508090223. Epub 2008 Jun 23.
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History
Started
Feb 2010
Main results due
Feb 2016
Finished
Mar 2016
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