DreaMS
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- DreaMS
What it measured
Main measures
Test Reliability of digital biomarkers measured by Intra Class Correlation
6 weeks
Blood or spinal fluid markersTest Reliability of digital biomarkers measured by Coefficient of variation
6 weeks
Blood or spinal fluid markersDetermination of user acceptance of each digital biomarker with regards to acceptance based on a questionnaire using a likert scale
6 weeks
Blood or spinal fluid markers
Who could take part
Relapsing and progressive · 18 to 70
Patients with MS Inclusion Criteria: * Age 18-70 * Diagnosed with MS according to the revised McDonald criteria 2017, all clinical forms inclusive (CIS, RRMS, SPMS, PPMS) * EDSS ≤ 6.5 * In possession of a smart phone Exclusion Criteria: * Age \<18 and > 70 * EDSS > 6.5 * Other clinically significant concomitant disease states (e.g., renal failure, severe hepatic dysfunction, severe/unstable cardiovascular disease, progressive cancer, etc.) * Known or suspected non-compliance, drug or alcohol abuse * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. * Women who are pregnant or breast feeding * Not in possession of a smart phone Healthy Volunteers Inclusion Criteria: * Age 18-70 * In possession of a smart phone Exclusion Criteria: * Age \<18 and > 70 * Diagnosis of MS * Clinically significant concomitant disease states (e.g., renal failure, severe hepatic dysfunction, severe/unstable cardiovascular disease, progressive cancer, etc.) * Known or suspected non-compliance, drug or alcohol abuse * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. * Women who are pregnant or breast feeding * Not in possession of a smart phone
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The Investigators have developed the dreaMS App, a data communication platform collecting data from the patients' mobile devices (smartphone and wearables). Through the use of app-based tests, surveys and sensor data, the Investigators aim to identify novel types of clinical data that can be used as digital biomarkers with complementary clinical value as compared to the traditional diagnostic methods and techniques. In this feasibility study a number of digital biomarkers will be applied to test their technical reproducibility/stability and meaningfulness to patients.
Papers
Results
Reliability and acceptance of dreaMS, a software application for people with multiple sclerosis: a feasibility study.J Neurol · 2023
Results
Pless S, Woelfle T, Naegelin Y, Lorscheider J, Wiencierz A, Reyes O, Calabrese P, Kappos L. Assessment of cognitive performance in multiple sclerosis using smartphone-based training games: a feasibility study. J Neurol. 2023 Jul;270(7):3451-3463. doi: 10.1007/s00415-023-11671-9. Epub 2023 Mar 23.
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Linked trials
Referred to by
DreaMS - Validation Study 1Running, not recruiting
Links found where a registry record names another trial's registry number.
History
Started
Oct 2020
Main results due
Feb 2021
Finished
Feb 2021
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