Aerobic Exercise for Remyelination in Multiple Sclerosis
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- Aerobic exercise
Compared with
- Education Group Control
Results by group
Somatosensory Evoked Potentials
From baseline to week 24
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| MS: Cycle | 3.83 Z-score | 3.25 (Standard Deviation) | 16 |
| MS: Take Control | 2.87 Z-score | 2.57 (Standard Deviation) | 16 |
| MS: Cycle | 3.22 Z-score | 3.22 (Standard Deviation) | 16 |
| MS: Take Control | 1.92 Z-score | 2.7 (Standard Deviation) | 16 |
MS: Cycle
MS: Take Control
MS: Cycle
MS: Take Control
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| MS: Cycle | 16 | 1 (6.3%) | 0 |
| MS: Take Control | 16 | 1 (6.3%) | 0 |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Somatosensory Evoked Potentials
From baseline to week 24
Myelin repair
Other measures (14)
6-Minute Timed Walk (6MTW)
From baseline to week 24
Walking and mobilityPhysical functionTimed Up and Go (TUG)
From baseline to week 24
Walking and mobilityTimed 25-Foot Walk (T25FW)
From baseline to week 24
Disability progressionWalking and mobility9 Hole Peg Test
From baseline to week 24
Disability progressionArm and hand functionMultiple Sclerosis Functional Composite (MSFC)
From baseline to week 24
Disability progressionThinking and memoryWalking and mobilityArm and hand functionVirtual Aerobic Exercise Intervention Adherence
From baseline to week 24
Physical functionQuality of life (reported by participants)Virtual Education Control Group Adherence
From baseline to week 24
Quality of life (reported by participants)Average Minutes Spent at Goal Heart Rate (HR) During Exercise
From baseline to week 24
Physical functionBrain Myelin Water Fraction (MWF)
From baseline to week 24
Myelin repairSymbol Digit Modalities Test (SDMT)
From baseline to week 24
Thinking and memory
Who could take part
MS (type not specified) · 18 to 64
Inclusion Criteria: * Physician-confirmed diagnosis of MS based on the 2017 McDonald criteria * 18-64 years old * Have access to the internet and a device that can access virtual visits * (Inclusion criteria to advance to clinical trial) Somatosensory evoked potential (SSEP) latency z-score ≥2 for P40 or inter-side difference in z-score ≥2 for P40 Exclusion Criteria: * Medical or biophysical conditions that prohibit the use of a cycle ergometer or treadmill (medical readiness to be assessed by the Activity Readiness Questionnaire (PAR-Q)) or achievement of target heart rate. * Engages in >30 minutes/week of aerobic activity regularly. * Clinically confirmed MS relapse in the last 3 months. * Changes in disease modifying therapy (DMT) for MS in the last 6 months. * Pregnant women. * Treatment with steroids for MS in the last 30 days. * Concurrent use of 4-aminopyridine or dalfampridine (medications which can alter SSEP) and unwilling to discontinue it for 2 days prior to SSEP testing. * Have a known history of severe spinal canal stenosis
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).
Papers
Loading reviews and guidelines…
History
Started
Apr 2021
Main results due
Mar 2025
Finished
Mar 2025
Results posted
Sept 2026
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