OVERLORD-MS

Treatment tested

• Rituximab

  B-lymphocyte antigen CD20 binding agent

• Ocrelizumab

  B-lymphocyte antigen CD20 binding agent

Compared with

• Ocrelizumab

  B-lymphocyte antigen CD20 binding agent

• Rituximab

  B-lymphocyte antigen CD20 binding agent

Other measures (55)

Inclusion Criteria: 1. Male and female patients, treatment naïve, and aged between 18 and 60 years included 2. Women of childbearing potential1 (WOCBP) able and willing to use highly effective methods of birth control2 per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly for the duration of the study OR until 3 months after last dose administered. 3. A diagnosis of RRMS according to the 2017 revised diagnostic criteria of McDonald (Thompson, Banwell et al. 2018) within the last 12 months. 4. Disease activity defined as ≥ 1 relapse3 or ≥ 1 new MRI lesion during the last 12 months 5. EDSS score ≤ 4.0 6. Absence of comorbidity or drug abuse that preclude study participation 7. Able to complete treatment or follow-up visits in the study (e.g. no contraindications for MRI or plans of moving) 8. Able to understand written and spoken Norwegian or English 9. Capable of giving signed informed consent as described in Appendix 1.2 which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. Exclusion Criteria: 1. Known hypersensitivity or other known side effects for any of the study medications, including co-medications such as high glucocorticosteroids 2. A diagnosis of primary progressive MS according to the revised diagnostic criteria of McDonald (Thompson, Banwell et al. 2018) 3. A disease course of secondary progressive MS (Lublin, Reingold et al. 2014) 4. Any ongoing infection, including tuberculosis, hepatitis virus or HIV, as well as hepatitis B surface antigen positivity and/or hepatitis C PCR positivity verified at screening visit. 5. Prior or current psychiatric illness, mental deficiency or cognitive dysfunction influencing the patient ability to make an informed consent or comply with the treatment and follow-up phases of this protocol. 6. Cardiac insufficiency, cardiomyopathy, significant cardiac dysrhythmia, unstable or advanced ischemic heart disease (NYHA III or IV) 7. Active malignancy or prior history of malignancy except localized basal cell, squamous skin cancer or carcinoma in situ of the cervix. 8. WBC \< 1.5 x 109/L if not caused by a reversible effect of documented ongoing medication. If WBC \< 1.5 x 109/L is caused by a reversible effect of documented ongoing medication the WBC count must be > 1,5 x 109/L before start of study treatment. 9. Platelet (thrombocyte) count \< 100 x 109/L 10. ALAT and/or ASAT more than 2 times the upper normal reference limit (ULN) 11. Serum creatinine > 200 µmol/L 12. Serum bilirubin > ULN 13. Pregnancy or lactating female patients 14. Any disease that can influence the patient safety and compliance, or the evaluation of disability 15. History of serious or life-threatening infusion reaction to ocrelizumab or rituximab, if previously treated with these medications for other diseases than MS 16. Previous use of MS-therapies such as natalizumab, fingolimod, interferons, glatiramer acetate, dimethyl fumarate, teriflunomide, cladribine, rituximab, alemtuzumab, ocrelizumab, hematopoietic stem cell therapy (HSCT) or other immunosuppression therapies with long lasting effects, or any other disease modifying therapy (DMT) for MS. If any of these medications have been used against other diseases than MS, patients can be included if the medications have not been used the previous year before enrollment. 17. Currently enrolled in another investigational device or drug study, or less than 30 days since ending another investigational device or drug study (s), or receiving other investigational treatment(s). Patients participating in a purely observational trial will not be excluded. 18. Presence of metallic objects implanted in the body, or allergy to MRI contrast that would preclude the ability of the patient to safely have MRI exams 19. Current alcohol or drug dependencies

This is a multicenter non-inferiority study, designed to establish non-inferiority of the study treatment rituximab compared with the comparator ocrelizumab for consecutively included patients (male or female) with active relapsing-remitting multiple sclerosis aged 18-60 years.