MUSCLE
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Nordic Walking (NWG)
- Free Walking (FWG)
- Health Education (HEG)
What it measured
Main measures
Test Timed Up and Go
Change from baseline at 12 weeks
Walking and mobilityLocomotor Rehabilitation Index
Change from baseline at 12 weeks
Self-selected walking speed
Change from baseline at 12 weeks
Walking and mobility
Other measures (5)
Optimal Walking Speed (OPT)
Change from baseline at 12 weeks
Walking and mobilityQuality of life (QoL)
Change from baseline at 12 weeks
Quality of life (reported by participants)Cognitive function
Change from baseline at 12 weeks
Thinking and memoryDepressive symptoms
Change from baseline at 12 weeks
Mood and sleepExpanded Disability Status Scale
Change from baseline at 12 weeks
Disability progressionRelapsesWalking and mobility
Who could take part
Progressive MS · 20 to 75
Inclusion Criteria: * volunteers aged over 20 years; * of both sexes; * with a clinical diagnosis of multiple sclerosis. Exclusion Criteria: * severe heart diseases, uncontrolled hypertension, myocardial infarction within a period of less than one year, being a pacemaker; * stroke or other associated neurological diseases; insanity; * prostheses in the lower limbs; * without ambulation conditions.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The aim of the study is to analyze the effects of Nordic Walking and free walking in the clinical-functional, postural balance, motor control, muscular echographic quality, and gait analysis (pendulum gait mechanism), in people with Multiple Sclerosis.
Papers
Results
Boeschoten RE, Braamse AMJ, Beekman ATF, Cuijpers P, van Oppen P, Dekker J, Uitdehaag BMJ. Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis. J Neurol Sci. 2017 Jan 15;372:331-341. doi: 10.1016/j.jns.2016.11.067. Epub 2016 Nov 30.Results
Casal MZ, Peyre-Tartaruga LA, Zanardi APJ, Ivaniski-Mello A, Alves LL, Haas AN, Martinez FG. Postural Adjustments and Biomechanics During Gait Initiation and Obstacle Negotiation: A Comparison Between Akinetic-Rigid and Hyperkinetic Parkinson's Disease. Front Physiol. 2021 Nov 4;12:723628. doi: 10.3389/fphys.2021.723628. eCollection 2021.Results
Cavagna GA, Willems PA, Legramandi MA, Heglund NC. Pendular energy transduction within the step in human walking. J Exp Biol. 2002 Nov;205(Pt 21):3413-22. doi: 10.1242/jeb.205.21.3413.Results
Frazzitta G, Balbi P, Maestri R, Bertotti G, Boveri N, Pezzoli G. The beneficial role of intensive exercise on Parkinson disease progression. Am J Phys Med Rehabil. 2013 Jun;92(6):523-32. doi: 10.1097/PHM.0b013e31828cd254.Results
Gomenuka NA, Bona RL, da Rosa RG, Peyre-Tartaruga LA. The pendular mechanism does not determine the optimal speed of loaded walking on gradients. Hum Mov Sci. 2016 Jun;47:175-185. doi: 10.1016/j.humov.2016.03.008. Epub 2016 Mar 24.Results
Gulde P, Hermsdorfer J, Rieckmann P. Speed but Not Smoothness of Gait Reacts to Rehabilitation in Multiple Sclerosis. Mult Scler Int. 2021 Jun 3;2021:5589562. doi: 10.1155/2021/5589562. eCollection 2021.Results
Halabchi F, Alizadeh Z, Sahraian MA, Abolhasani M. Exercise prescription for patients with multiple sclerosis; potential benefits and practical recommendations. BMC Neurol. 2017 Sep 16;17(1):185. doi: 10.1186/s12883-017-0960-9.Results
Hobart JC, Riazi A, Lamping DL, Fitzpatrick R, Thompson AJ. Measuring the impact of MS on walking ability: the 12-Item MS Walking Scale (MSWS-12). Neurology. 2003 Jan 14;60(1):31-6. doi: 10.1212/wnl.60.1.31.Results
Kelleher KJ, Spence W, Solomonidis S, Apatsidis D. The characterisation of gait patterns of people with multiple sclerosis. Disabil Rehabil. 2010;32(15):1242-50. doi: 10.3109/09638280903464497.Results
Kim Y, Lai B, Mehta T, Thirumalai M, Padalabalanarayanan S, Rimmer JH, Motl RW. Exercise Training Guidelines for Multiple Sclerosis, Stroke, and Parkinson Disease: Rapid Review and Synthesis. Am J Phys Med Rehabil. 2019 Jul;98(7):613-621. doi: 10.1097/PHM.0000000000001174.
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History
Started
Aug 2022
Main results due
Dec 2022
Finished
Dec 2024
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