ACT with NMOSD Patients and Caregivers Pilot Study
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Acceptance and Commitment Therapy
What it measured
Main measures
Changes in Generalized Anxiety Disorder Questionnaire (GAD7)
Baseline, 6 weeks, and three months after study completion.
Mood and sleepChanges in Patient Health Questionnaire (PHQ-9)
Baseline, 6 weeks, and three months after study completion.
Mood and sleepChanges in Beck Anxiety Inventory (BAI)
Baseline, 6 weeks, and three months after study completion.
Mood and sleepChanges in Beck Depression Inventory (BDI-II)
Baseline, 6 weeks, and three months after study completion.
Mood and sleep
Other measures (6)
Acceptance and Action Questionnaire- version 2 (AAQ-II)
Baseline, 6 weeks, and three months after study completion.
Bladder, bowel and sexual functionCognitive Fusion Questionnaire - 13 item version
Baseline, 6 weeks, and three months after study completion.
Thinking and memoryBrief Fatigue Inventory
3 months prior to baseline to baseline, baseline to 3 months post-treatment
FatigueTelephone EDSS
Baseline, 6 weeks, and three months after study completion.
Disability progressionValued Living Questionnaire
Baseline, 6 weeks, and three months after study completion.
EHR data re. NMOSD flares, hospitalization, appointments kept/missed
3 months prior to baseline to baseline, baseline to 3 months post-treatment
Who could take part
NMOSD · 18 and over
Inclusion Criteria: * Individuals ages 18 and up with a diagnosis of NMOSD and caregiver loved ones willing to participate in the intervention. * PHQ-9 score >4, or GAD-7 score >4 * Webcam access Exclusion Criteria: * History of suicidal attempts or acute suicidal ideation on clinical assessment * Presence of psychotic disorder or symptoms * Presence of psychiatric disorders that interfere with the participation of the study, judged by the study or treating clinician. The presence of other medical conditions that interfere with participation in the study, judged by the study or treating clinician
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study will examine the effectiveness of a neuromyelitis optics spectrum disorder (NMOSD) specific Acceptance and Commitment Therapy (ACT) intervention at reducing anxiety and depression in individuals with NMOSD and their caregivers/loved ones and improving overall health outcomes in individuals with NMOSD.
Papers
Results
ACT with NMOSD: A targeted, telehealth-delivered mental health intervention for patients & caregivers.Mult Scler Relat Disord · 2025
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History
Started
Aug 2023
Main results due
Sept 2024
Finished
Nov 2024
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