Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis

Inclusion Criteria: * Patients affected by primary progressive or relapsing remitting multiple sclerosis * Patient able to provide informed consent Exclusion Criteria: * Individuals with \< 18 years * Patients not affected by primary progressive or relapsing remitting multiple sclerosis

The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Specific aims are: 1) identify mitochondrial-related pathways, inherited and somatic mitochondrial DNA mutations associated to primary progressive multiple sclerosis, 2) functionally assess the identified genetic alterations.