Lifestyle Physical Activity Intervention for Persons Newly Diagnosed With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- Physical activity condition
- Waitlist condition
What it measured
Main measures
Physical Activity Behavior
Changes in the GLTEQ scores from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Physical functionPhysical Activity Behavior
Changes in the IPAQ scores from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Physical functionPhysical Activity Level (Light physical activity)
Changes in time spent in LPA from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Physical functionPhysical Activity Level (Moderate-to-vigorous physical activity)
Changes in time spent in MVPA from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Physical functionPhysical Activity Level (Daily step count)
Changes in time spent in daily step count from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Physical function
Other measures (5)
Health-related quality of Life
Changes in SF-12 scores from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Quality of life (reported by participants)Health-related Quality of Life
Changes in MSIS-29 scores from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Quality of life (reported by participants)Fatigue Severity
Changes in fatigue severity scores from Baseline (pre-intervention) and after 16 weeks (post-intervention)
FatigueDepressive Symptoms
Changes in depressive symptoms scores from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Mood and sleepAnxiety
Changes in anxiety scores from Baseline (pre-intervention) and after 16 weeks (post-intervention)
Mood and sleep
Who could take part
MS (type not specified) · 18 and over
Inclusion Criteria: * aged 18 years or older * self-reported diagnosis of MS by a neurologist within the past 2 years * relapse-free for the past 30 days * ability to speak and read English as primary language * internet and e-mail access, and willingness to complete the testing and questionnaires * ambulatory without an assistive device (e.g., cane) * insufficiently active (Godin Leisure-Time Exercise Questionnaire (GLTEQ) \< 14) * visual ability and literacy to read newsletter with font size 14 points * on a disease-modifying therapy. Exclusion Criteria: * pregnant * have elevated risk for undertaking strenuous or maximal exercise based on two or more affirmatives on the Physical Activity Readiness Questionnaire (PAR-Q)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The overall objective of the current study is to determine the efficacy of a 16-week remotely delivered lifestyle behavioral intervention compared with a control condition (i.e., waitlist control) in persons newly diagnosed with MS (disease duration ≤ 2 years). Specific Aim 1: To evaluate the changes in self-report and device-measured physical activity after the 16-week remotely delivered physical activity behavior change intervention compared with a control condition (i.e., waitlist control) in persons who have diagnosed with MS within the past two years. The investigators hypothesize that the 16-week behavior change intervention will yield greater improvements in physical activity levels than the control condition immediately after the intervention. Specific Aim 2: To investigate the efficacy of the 16-week, remotely delivered physical activity behavior change intervention compared with the control condition for improvements in fatigue, depression, anxiety, and QoL in persons newly diagnosed with MS. The investigators hypothesize that there will be beneficial effects on the symptoms and QoL outcomes immediately after the physical activity intervention compared with minimal changes in the control condition.
Papers
Results
Results of a pilot randomized controlled trial of a COM-B-based physical activity behavior-change intervention in people newly diagnosed with multiple sclerosis.Mult Scler Relat Disord · 2026
Results
Theory-based physical activity behavior change intervention in people newly diagnosed with multiple sclerosis: Study protocol for a pilot randomized controlled trial.Contemp Clin Trials · 2025
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History
Started
Apr 2024
Main results due
Aug 2026
Finished
Dec 2026
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