RecruitingNot a drug-phase studyProgressive MSNCT06495138

What it found

Still running

No result yet.

What was tested

Treatment tested

  • StableEyes

What it measured

Main measures

  • Composite VOR gain (cVOR gain)

    Weeks 0,1,2,3,4,5,6, 7, and 18

Other measures (9)

  • Best Corrected Dynamic Visual Acuity (During Head Movements)

    Weeks 0,1, 4, 7, and 18

    VisionWalking and mobility
  • Balance Evaluation Systems Test Total Score

    Weeks 1, 4, 7, and 18

    Walking and mobility
  • Gait Disorientation Test (GDT) Score

    Weeks 1, 4, 7, and 18

    Walking and mobility
  • Dizziness Handicap Inventory Total Score

    Weeks 1, 4, 7, and 18

  • Activities-specific Balance Confidence Scale Average Score

    Weeks 1, 4, 7, and 18

    Walking and mobility
  • Oscillopsia Visual Analog Scale Score

    Weeks 1, 4, 7, and 18

    VisionWalking and mobility
  • Disequilibrium Visual Analog Scale Score

    Weeks 1, 4, 7, and 18

    Walking and mobility
  • Multiple Sclerosis Quality of Life - 54 (MSQOL-54) Total Score

    Weeks 1, 4, 7, and 18

    Thinking and memoryFatigueQuality of life (reported by participants)
  • Global Perception of Effect Score

    Weeks 1, 4, 7, and 18

Who could take part

Progressive MS · 18 to 89

Inclusion Criteria: * Neurologist-confirmed diagnosis of primary progressive or relapsing and remitting MS per The 2017 Revision of the McDonald Criteria and the Magnetic Resonance Imaging in MS, or a healthy volunteer without a diagnosis of multiple sclerosis or any related neurological conditions * Fluent in speaking and understanding English * Subjects with multiple sclerosis have self-reported vestibular symptoms of dizziness, imbalance, and/or a history of at least two falls in the prior 12 months Exclusion Criteria: * Clinically isolated syndrome or radiologically isolated syndrome. * Worsening MS symptoms during the prior 60 days * Immunotherapy change in the prior 60 days * Self-reported cognitive impairment that limits independence with basic and instrumental activities of daily living * Systolic blood pressure > 180 mmHg and/or diastolic blood pressure > 90 mmHg at rest * Static visual acuity with correction of worse than 1.0 logMAR * Manifest ocular misalignment ≥ 5 diopters (e.g., tropia, lazy eye, strabismus} * Convergence insufficiency * Intra-nuclear ophthalmoplegia * Vestibular Migraine * Major orthopedic conditions that limit cervical spine range of motion or that alter walking * Self-reported current or potential for pregnancy during enrollment * Ongoing participation in vestibular rehabilitation for dizziness

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosis.

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History

    1. Started

      Apr 2025

    2. Main results due

      Oct 2027

    3. Finished

      Oct 2027

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