DIIVA-MS
What it found
No result yet.
What was tested
Treatment tested
- StableEyes
What it measured
Main measures
Composite VOR gain (cVOR gain)
Weeks 0,1,2,3,4,5,6, 7, and 18
Other measures (9)
Best Corrected Dynamic Visual Acuity (During Head Movements)
Weeks 0,1, 4, 7, and 18
VisionWalking and mobilityBalance Evaluation Systems Test Total Score
Weeks 1, 4, 7, and 18
Walking and mobilityGait Disorientation Test (GDT) Score
Weeks 1, 4, 7, and 18
Walking and mobilityDizziness Handicap Inventory Total Score
Weeks 1, 4, 7, and 18
Activities-specific Balance Confidence Scale Average Score
Weeks 1, 4, 7, and 18
Walking and mobilityOscillopsia Visual Analog Scale Score
Weeks 1, 4, 7, and 18
VisionWalking and mobilityDisequilibrium Visual Analog Scale Score
Weeks 1, 4, 7, and 18
Walking and mobilityMultiple Sclerosis Quality of Life - 54 (MSQOL-54) Total Score
Weeks 1, 4, 7, and 18
Thinking and memoryFatigueQuality of life (reported by participants)Global Perception of Effect Score
Weeks 1, 4, 7, and 18
Who could take part
Progressive MS · 18 to 89
Inclusion Criteria: * Neurologist-confirmed diagnosis of primary progressive or relapsing and remitting MS per The 2017 Revision of the McDonald Criteria and the Magnetic Resonance Imaging in MS, or a healthy volunteer without a diagnosis of multiple sclerosis or any related neurological conditions * Fluent in speaking and understanding English * Subjects with multiple sclerosis have self-reported vestibular symptoms of dizziness, imbalance, and/or a history of at least two falls in the prior 12 months Exclusion Criteria: * Clinically isolated syndrome or radiologically isolated syndrome. * Worsening MS symptoms during the prior 60 days * Immunotherapy change in the prior 60 days * Self-reported cognitive impairment that limits independence with basic and instrumental activities of daily living * Systolic blood pressure > 180 mmHg and/or diastolic blood pressure > 90 mmHg at rest * Static visual acuity with correction of worse than 1.0 logMAR * Manifest ocular misalignment ≥ 5 diopters (e.g., tropia, lazy eye, strabismus} * Convergence insufficiency * Intra-nuclear ophthalmoplegia * Vestibular Migraine * Major orthopedic conditions that limit cervical spine range of motion or that alter walking * Self-reported current or potential for pregnancy during enrollment * Ongoing participation in vestibular rehabilitation for dizziness
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosis.
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History
Started
Apr 2025
Main results due
Oct 2027
Finished
Oct 2027
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