Motor Imagery and Action Observation for Gait Function in MS
What it found
No result yet.
What was tested
Treatment tested
- Action Observation + Motor Imagery
- Nature Video
What it measured
Main measures
Change in Tibialis Anterior and Gastrocnemius Medialis Muscle Activity Amplitude
Before and immediately after the intervention
Walking and mobilityChange in Tibialis Anterior and Gastrocnemius Medialis Muscle Activity Onset Latency
Before and immediately after the intervention.
Myelin repairWalking and mobilityChange in Step Length
Before and immediately after the intervention
Walking and mobilityChange in Step Time
Before and immediately after the intervention
Walking and mobilityChange in Step Width
Before and immediately after the intervention
Walking and mobilityChange in Double Support Period
Before and immediately after the intervention
Walking and mobilityChange in Gait Velocity
Before and immediately after the intervention
Walking and mobilityChange in Cadence
Before and immediately after the intervention
Walking and mobility
Other measures (8)
Motor Imagery Vividness
Baseline only
Mental Chronometry Ratio
Baseline only
Walking and mobilityLimb Laterality Recognition Performance
Baseline only
Thinking and memoryCognitive Status
Baseline only
Thinking and memoryFatigue Level
Baseline only
FatigueAnxiety and Depression
Baseline only
Mood and sleepDisability Level
Baseline only
Disability progressionVisionWalking and mobilityVisual Acuity
Baseline only
Vision
Who could take part
MS (type not specified) · 18 and over
Inclusion Criteria: * A confirmed diagnosis of multiple sclerosis (MS) by a neurologist * No history of relapse within the past 3 months and not currently experiencing a relapse * A score of 24 or higher on the standardized Mini Mental State Examination Exclusion Criteria: * Presence of serious health conditions affecting the muscles, heart, lungs, or metabolism that could interfere with participation * History of other neurological disorders, head injury, or chronic psychiatric conditions * Chronic pain lasting longer than six months * Significant muscle stiffness in the legs that may affect EMG recordings * Hearing difficulties * Vision problems as determined by the Snellen visual acuity test
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This study will investigate whether mentally simulating walking movements while watching others walk can improve walking performance in individuals with Multiple Sclerosis (MS). Participants will be divided into two groups: one group will watch walking videos and imagine themselves walking, while the other group will watch nature scenes. The study will measure muscle activity and walking patterns to assess the effects. The results may help support the use of mental practice techniques to improve mobility in people with MS.
Papers
Results
Wright DJ, Williams J, Holmes PS. Combined action observation and imagery facilitates corticospinal excitability. Front Hum Neurosci. 2014 Nov 27;8:951. doi: 10.3389/fnhum.2014.00951. eCollection 2014.Results
Rocca MA, Meani A, Fumagalli S, Pagani E, Gatti R, Martinelli-Boneschi F, Esposito F, Preziosa P, Cordani C, Comi G, Filippi M. Functional and structural plasticity following action observation training in multiple sclerosis. Mult Scler. 2019 Oct;25(11):1472-1487. doi: 10.1177/1352458518792771. Epub 2018 Aug 7.Results
Gil-Bermejo-Bernardez-Zerpa A, Moral-Munoz JA, Lucena-Anton D, Luque-Moreno C. Effectiveness of Motor Imagery on Motor Recovery in Patients with Multiple Sclerosis: Systematic Review. Int J Environ Res Public Health. 2021 Jan 9;18(2):498. doi: 10.3390/ijerph18020498.Results
Chye S, Valappil AC, Wright DJ, Frank C, Shearer DA, Tyler CJ, Diss CE, Mian OS, Tillin NA, Bruton AM. The effects of combined action observation and motor imagery on corticospinal excitability and movement outcomes: Two meta-analyses. Neurosci Biobehav Rev. 2022 Dec;143:104911. doi: 10.1016/j.neubiorev.2022.104911. Epub 2022 Nov 5.Results
Salamci M, Salci Y, Topuz S, Yalcin AI, Acar Ozen P, Tuncer A. Gait initiation in multiple sclerosis patients with and without functional loss. Mult Scler Relat Disord. 2023 Nov;79:104990. doi: 10.1016/j.msard.2023.104990. Epub 2023 Sep 4.
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History
Started
Jan 2026
Main results due
Nov 2026
Finished
Nov 2026
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