VR-based Dexterity Training in MS
What it found
No result yet.
What was tested
Treatment tested
- VR-based dexterity training in MS
Placebo or sham
- mediation program
What it measured
Main measures
Arm Function Score in Multiple Sclerosis Questionnaire
4 weeks
Arm and hand function
Other measures (5)
Time for completing the Nine-hole-Peg-Test (9HPT)
4 weeks
Disability progressionArm and hand functionTime for completion the Coin rotation task (CRT)
4 Weeks
Arm and hand functionThe highest strength value resulting from the Handheld JAMAR dynamometer
4 Weeks
Arm and hand functionPhysical functionValue resulting from the Multiple Sclerosis Impact Scale 29 (MSIS 29)
4 Weeks
Quality of life (reported by participants)Scores of the Electronic Neurostatus-Expanded Disability Status Scale (eEDSS) (D'Souza M et al. 2020)
4 Weeks
Disability progressionArm and hand function
Who could take part
Relapsing and progressive · 18 to 75
Inclusion Criteria: * MS patients with relapsing-remitting MS (RRMS), secondary-progressive MS (SPMS) or primary progressive MS (PPMS) according to the revised McDonald's criteria (Thompson et al. 2017) * Age between 18 and 75 years * Written informed consent signed by the subject must be obtained prior to study start * Patient must complain about MS related impaired manual dexterity negatively affecting ADL and/or QoL * Patients must have Arm function in multiple sclerosis questionnaire (AMSQ) score >41 Exclusion Criteria: * A relapse that started within 60 days prior to screening * Rapidly progressive disease * Any disease/condition that impaired manual dexterity besides MS * Any disease other than MS that could possibly explain the patient's signs and symptoms * Medical or psychiatric conditions that compromise the ability to comply with the protocol, or to complete the study * History of epilepsy or epileptic seizures * A history of drug abuse in the 12 months prior to screening
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The aim of the study is to investigate if a specifically developed home-based dexterity training intervention using a Virtual Reality (VR) Headset (Meta quest 2) improves impaired manual dexterity in persons with multiple sclerosis.
Papers
Background
Yancosek KE, Howell D. A narrative review of dexterity assessments. J Hand Ther. 2009 Jul-Sep;22(3):258-69; quiz 270. doi: 10.1016/j.jht.2008.11.004. Epub 2009 Feb 12.Background
Winberg C, Kylberg M, Pettersson C, Harnett T, Hedvall PO, Mattsson T, Mansson Lexell E. The Use of Apps for Health in Persons with Multiple Sclerosis, Parkinson's Disease and Stroke - Barriers and Facilitators. Stud Health Technol Inform. 2017;242:638-641.Background
Vanbellingen T, van Beek J, Nyffeler T, Urwyler P, Nef T, Bohlhalter S. Tablet app-based dexterity-training in patients with Parkinson's disease: Pilot feasibility study. Ann Phys Rehabil Med. 2021 Jul;64(4):101419. doi: 10.1016/j.rehab.2020.06.004. Epub 2020 Oct 6. No abstract available.Background
van Beek JJW, van Wegen EEH, Rietberg MB, Nyffeler T, Bohlhalter S, Kamm CP, Nef T, Vanbellingen T. Feasibility of a Home-Based Tablet App for Dexterity Training in Multiple Sclerosis: Usability Study. JMIR Mhealth Uhealth. 2020 Jun 9;8(6):e18204. doi: 10.2196/18204.Background
van Beek JJW, van Wegen EEH, Bol CD, Rietberg MB, Kamm CP, Vanbellingen T. Tablet App Based Dexterity Training in Multiple Sclerosis (TAD-MS): Research Protocol of a Randomized Controlled Trial. Front Neurol. 2019 Feb 11;10:61. doi: 10.3389/fneur.2019.00061. eCollection 2019.Background
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintore M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA. Diagnosis of multiple sclerosis: 2017 revisionsBackground
Thirumalai M, Rimmer JH, Johnson G, Wilroy J, Young HJ, Mehta T, Lai B. TEAMS (Tele-Exercise and Multiple Sclerosis), a Tailored Telerehabilitation mHealth App: Participant-Centered Development and Usability Study. JMIR Mhealth Uhealth. 2018 May 24;6(5):e10181. doi: 10.2196/10181.Background
Tacchino A, Pedulla L, Bonzano L, Vassallo C, Battaglia MA, Mancardi G, Bove M, Brichetto G. A New App for At-Home Cognitive Training: Description and Pilot Testing on Patients with Multiple Sclerosis. JMIR Mhealth Uhealth. 2015 Aug 31;3(3):e85. doi: 10.2196/mhealth.4269.Background
Steinheimer S, Wendel M, Vanbellingen T, Westers LT, Hodak J, Blatter V, Uitdehaag BMJ, Kamm CP. The Arm Function in Multiple Sclerosis Questionnaire was successfully translated to German. J Hand Ther. 2018 Jan-Mar;31(1):137-140.e1. doi: 10.1016/j.jht.2017.09.010. No abstract available.Background
Riazi A, Hobart JC, Lamping DL, Fitzpatrick R, Thompson AJ. Multiple Sclerosis Impact Scale (MSIS-29): reliability and validity in hospital based samples. J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):701-4. doi: 10.1136/jnnp.73.6.701.
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History
Started
May 2026
Main results due
May 2028
Finished
May 2028
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