MIVR-MS
What it found
No result yet.
What was tested
Treatment tested
- Motor Imagery + Vestibular Rehabilitation group
- Conventional therapy group
What it measured
Main measures
Change in Cognitive Function (Montreal Cognitive Assessment [MoCA] Score)
Baseline and 8 weeks after intervention
Thinking and memoryChange in Balance Berg Balance Scale \[ABBS] Score)
Baseline (Week 0) and Post-intervention (Week 8)
Walking and mobilityChange in Vestibular Function (Dynamic Visual Acuity [DVA] Test)
Baseline and Week 8.
VisionWalking and mobilityChange in Vestibular Function (Head Impulse Test [HIT])
Baseline and Week 8
VisionNerve conduction testsChange in Cognitive Function (Brief International Cognitive Assessment for MS \[BICAMS] Composite Score
Baseline (Week 0) and Post-intervention (Week 8)
Thinking and memoryChange in balance (Timed Up and Go [TUG] Time)
Baseline and Week 8
Walking and mobilityChange in Disability Status (Patient-Determined Disease Steps \[PDDS] Score)
Baseline and Week 8.
Other measures (1)
Change in Quality of Life (Multiple Sclerosis Impact Scale-29 \[MSIS-29]
Baseline and Week 8.
Quality of life (reported by participants)
Who could take part
Relapsing MS · 18 to 45
inclusion criteria 1. Diagnosis of Multiple Sclerosis (MS) Confirmed using McDonald Criteria 2. Patient diagnosed relapsing-remitting multiple sclerosis (RRMS). 3. Mild MS between 0-3 according to PDDS. 4. Age from (18-45) 5. Mild cognitive impairment 6. Balance impairment (mild to moderate impairment) 7. Vestibular dysfunction Related to MS (dizziness, vertigo , gaze instability ) 8. Native language is Arabic to ensure clear communication during cognitive tasks and exercise instructions 9. Be able to joined the treatment (motor imagery, vestibular rehabilitaiton ) Exclusion Criteria: Other neurological disorder, progressive multiple sclerosis Non-MS related vestibular disorders (e.g., BPPV, Meniere's disease) that would interfere with vestibular rehab. Severe Psychiatric Conditions (schizophrenia, bipolar, etc) Sever balance disorder Sever fatigue Medical instability eg (cardiovascular disease, respiratory, infections, severe uncontrolled diabetes, or severe visual impairments.) Sever cognitive impairment Pregnant Advance disability ( wheelchair , unable to stand ) Use of Vestibular-Suppressing Medications Non - speaker Arabic
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This trial investigates the first combined use of motor imagery and vestibular rehabilitation in multiple sclerosis, aiming to evaluate their joint effect on balance, cognition, and quality of life.
Papers
Results
Garcia-Munoz C, Cortes-Vega MD, Heredia-Rizo AM, Martin-Valero R, Garcia-Bernal MI, Casuso-Holgado MJ. Effectiveness of Vestibular Training for Balance and Dizziness Rehabilitation in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis. J Clin Med. 2020 Feb 21;9(2):590. doi: 10.3390/jcm9020590.Background
Ozgen G, Karapolat H, Akkoc Y, Yuceyar N. Is customized vestibular rehabilitation effective in patients with multiple sclerosis? A randomized controlled trial. Eur J Phys Rehabil Med. 2016 Aug;52(4):466-78. Epub 2016 Apr 6.Background
Abraham A, Hart A, Andrade I, Hackney ME. Dynamic Neuro-Cognitive Imagery Improves Mental Imagery Ability, Disease Severity, and Motor and Cognitive Functions in People with Parkinson's Disease. Neural Plast. 2018 Mar 14;2018:6168507. doi: 10.1155/2018/6168507. eCollection 2018.Background
Aljarallah S, Alkhathlan H, Almushawah A, Badahdah A, Alfaifi N, Abdulmaged-Ahmed DA, Alkhawajah NM. Performance of an Arabic translation of the patient determined disease steps (PDDS) scale in Saudi patients with multiple sclerosis. Medicine (Baltimore). 2023 Nov 3;102(44):e35889. doi: 10.1097/MD.0000000000035889.Background
Rahman TT, El Gaafary MM. Montreal Cognitive Assessment Arabic version: reliability and validity prevalence of mild cognitive impairment among elderly attending geriatric clubs in Cairo. Geriatr Gerontol Int. 2009 Mar;9(1):54-61. doi: 10.1111/j.1447-0594.2008.00509.x.Background
Manago MM, Schenkman M, Berliner J, Hebert JR. Gaze stabilization and dynamic visual acuity in people with multiple sclerosis. J Vestib Res. 2016;26(5-6):469-477. doi: 10.3233/VES-160593.Background
Mulder T. Motor imagery and action observation: cognitive tools for rehabilitation. J Neural Transm (Vienna). 2007;114(10):1265-78. doi: 10.1007/s00702-007-0763-z. Epub 2007 Jun 20.Background
Urgesi C, Moro V, Candidi M, Aglioti SM. Mapping implied body actions in the human motor system. J Neurosci. 2006 Jul 26;26(30):7942-9. doi: 10.1523/JNEUROSCI.1289-06.2006.Background
Volz MS, Suarez-Contreras V, Portilla AL, Fregni F. Mental imagery-induced attention modulates pain perception and cortical excitability. BMC Neurosci. 2015 Mar 15;16:15. doi: 10.1186/s12868-015-0146-6.Background
Khan F, Amatya B. Rehabilitation in Multiple Sclerosis: A Systematic Review of Systematic Reviews. Arch Phys Med Rehabil. 2017 Feb;98(2):353-367. doi: 10.1016/j.apmr.2016.04.016. Epub 2016 May 20.
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History
Started
Dec 2025
Main results due
May 2026
Finished
Jul 2026
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