RecruitingRelapsing and progressiveNCT07815990

What it found

Still running

No result yet.

What it measured

Main measures

  • 6-Minute Walk Test

    Day 1

    Walking and mobilityPhysical function

Other measures (6)

  • Timed 25-Step Walking Test

    Day 1

    Disability progressionWalking and mobility
  • Dual Task Performance Test: Standing (Static Balance) Tasks

    Day 1

    Walking and mobility
  • Dual Task Performance Test: Walking (Dynamic Balance) Tasks

    Day 1

    Walking and mobility
  • Berg Balance Scale

    Day 1

    Walking and mobilityMood and sleep
  • Activity-Specific Balance Confidence Scale

    Day 1

    Walking and mobility
  • Modified Fatigue Impact Scale

    Day 1

    Thinking and memoryFatigueQuality of life (reported by participants)

Who could take part

Relapsing and progressive · 18 to 65

Inclusion Criteria: * Having been diagnosed with Relapsing-Remitting or Progressive MS. * Being between 18-65 years of age. * Having an Expanded Disability Status Scale score between 1.5-5. * Being able to walk independently or with a unilateral assistive device. * Having full cooperation and orientation, and a cognitive level to understand given commands: Mini Mental Test score of 24 or higher. Exclusion Criteria: * Having experienced an MS relapse or received acute corticosteroid treatment within the last 3 months. * Having an additional neurological, orthopedic, or rheumatological condition unrelated to MS that may affect balance and walking. * Having severe cardiovascular or respiratory disease that may make aerobic fitness assessment risky. * Having significant vision or hearing loss that would impede understanding test instructions. * Experiencing significant pain during measurements. * Having cognitive impairment that would prevent understanding or answering questions - scoring below 24 on the Minimental Test.

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

The aim of this study is to comparatively examine the effect of aerobic fitness levels on walking and balance performance, sensory dual-task (proprioceptive and vestibular) performance, balance confidence, and fatigue levels in individuals diagnosed with MS. Research hypotheses H1: MS patients with high aerobic fitness exhibit superior walking speed and balance performance compared to MS patients with low aerobic fitness. H2: In sensory dual-task tests involving proprioceptive and vestibular manipulations (BOSU ball, soft surface, and head movements synchronized with a metronome), MS patients with high aerobic fitness demonstrate better performance than the group with low aerobic fitness. H3: MS patients with high aerobic fitness report higher levels of balance confidence compared to the group with low aerobic fitness. H4: Perceived fatigue is greater in MS patients with low aerobic fitness compared to the group with high aerobic fitness. H5: There is a significant relationship between aerobic capacity levels and sensory dual-task performance, balance confidence, and fatigue severity in MS patients.

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History

  1. Status changed from Not yet recruiting to Recruiting
  1. Started

    Sept 2026

  2. Main results due

    Jan 2027

  3. Finished

    May 2027

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