DTBinMS
What it found
No result yet.
What was tested
Treatment tested
- Dual-task balance training
What it measured
Main measures
Retention rate
Week 7 after baseline
MRI lesionsFeasibilityAdherence to the training
From baseline to the end of intervention phase (7 weeks)
Quality of life (reported by participants)
Other measures (31)
Assessment burden
Baseline and week 7 after baseline
Change in timed up and go dual-task cost
From baseline to the end of intervention phase (7 weeks)
Walking and mobilityChange in 2 minutes walking test dual-task cost
From baseline to the end of intervention phase (7 weeks)
Walking and mobilityChange in cognitive dual-task cost
From baseline to the end of intervention phase (7 weeks)
Thinking and memoryChange in EEG Task Load Index
From baseline to the end of intervention phase (7 weeks)
Walking and mobilityNerve conduction testsChange in prefrontal EEG theta power
From baseline to the end of intervention phase (7 weeks)
Walking and mobilityNerve conduction testsChange in perceived workload
From baseline to the end of intervention phase (7 weeks)
Change in perceived fatigue
From baseline to the end of intervention phase (7 weeks)
FatiguePatient Global Impression of Change
At the end of the intervention phase (week 7 after baseline)
Change in MSWS-12
From baseline to the end of intervention phase (7 weeks)
Walking and mobility
Who could take part
Relapsing and progressive · 18 to 75
Inclusion Criteria: * Age 18 to 75 years * Diagnosis of multiple sclerosis (relapsing-remitting, primary progressive or secondary progressive) * Timed Up and Go test > 8.4 s * Expanded Disability Status Scale (EDSS) score \< 7 * Able to walk independently for 2 minutes * Written informed consent Exclusion Criteria: * Other conditions that may affect motor function * Cognitive impairment (Mini-Mental State Examination score \< 24) * Severe visual deficits
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The goal of this randomized controlled feasibility study is to assess whether a balance training program that includes dual-task exercises is feasible in people with multiple sclerosis (MS). The study also aims to obtain preliminary data on the effects of the training on walking under dual-task conditions and on brain activity recorded with a wearable EEG. The main questions it aims to answer are: * Is the training feasible in terms of recruitment, retention, adherence, data completeness, and assessment burden? * What are the preliminary effects of the training on dual-task costs during the Timed Up and Go test (TUG) and the 2-Minute Walk Test (2MWT), on prefrontal activation and mental workload during walking, and on clinical outcomes? Researchers will compare participants who receive the training with participants who receive no additional rehabilitation during the study period. Participants will: * receive 14 in-hospital sessions of balance and dual-task training (60 minutes, 2 sessions per week, about 7 weeks) if allocated to the intervention group, or no new rehabilitation if allocated to the control group; * perform a dual-task walking assessment (TUG, 2MWT, backward digit span) while wearing an 8-channel wearable EEG headset and 3 inertial sensors, before (T0) and after (T1) the study period; * complete clinical scales and questionnaires on balance, gait, cognition, fatigue, mood, pain, and quality of life.
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History
Started
Oct 2026
Main results due
Jul 2029
Finished
Sept 2029
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