MST3K

Treatment tested

• Liothyronine

  Thyroid hormone receptor agonist

Placebo or sham

• Placebo

Other measures (1)

Inclusion Criteria: * Confirmed diagnosis of MS of any type * Age 18 to 50 years * Weight range 45-90 kg (100-200 lbs) * Lesions on brain MRI Exclusion Criteria: * History of hypo or hyperthyroidism and a normal TSH * History of high blood pressure (hypertension) [ * Resting blood pressure greater than 150/95, resting heart rate greater than 100 * History of coronary artery disease or clinically significant arrhythmia, clinically significant abnormalities on EKG * History of diabetes * History of anemia or renal (kidney) disease * Clinically significant abnormalities on metabolic panel or serum hematocrit below 32 % * History of atrophic gastritis * History of anxiety disorder or bipolar disorder * Serious psychiatric or medical conditions that would preclude reliable participation in the study * Use of illicit substances or alcohol abuse * Current use of fingolimod (Gilenya) * Current or prior use of mitoxantrone (Novantrone) * Current use of stimulants (methylphenidate, atomoxetine, dextroamphetamine,phentermine) * Current use of any blood thinners such as warfarin or apixaban (Aspirin is ok) * Medications which would metabolized faster in the presence of thyroid hormone (Insulin, oral hypoglycemic agents and oral anticoagulants) * Severe head tremors (which would impair the ability to perform VEPs) * Present or recent use of medications that could interact with the thyroid hormone (iodine containing agents such as kelp supplements, amiodarone, iodinated contrast given for CT or xray), P450 stimulants (phenytoin, carbamazepine, phenobarbital, and rifampin) * Corrected visual acuity worse than 20/50 in either eye or other eye issues that would prevent reading of a standard eye chart * Head tremors or other tremors that would prevent sitting relatively still for a vision test * Patients taking proton pump inhibitors (PPIs) or H2 blockers will be excluded unless they can safely not take these medications during the week of study drug administration. * Patients taking Ampyra (dalfampridine) will be excluded unless they can safely not take these medications during the week of study drug administration. * Pregnancy, breastfeeding, or intention to become pregnant in the following month * Inability to receive an MRI (e.g. implanted metal device)

This is a phase 1 study evaluating the safety and maximum tolerated dose of Liothyronine (T3) in subjects with multiple sclerosis