Failed early
Interferon beta: slow disability worsening in relapsing MS
relapsing MS · Interferon beta
Controlled phase 2 trials were negative.
- Trials
- 10
- Running now
- 1
- Controlled phase 2/3 trials
- 2
- People in controlled trials
- 267
Deciding trials (phase 2): 0 met, 1 did not.
Other linked trials: 9
Dose comparisons, trials against another medicine, add-on trials, phase 1 and uncontrolled studies. They are listed below but do not set the status.
Trials
Phase 2 · 2018 · Placebo-controlled · MSFT-NCT03387046
Phase 2 · 2011 · Placebo-controlled · MSFT-NCT01285401
At 48 weeks, 36.3% of patients who received high-dose vitamin D 3 had NEDA-3, without a statistically significant difference in NEDA-3 status between groups (placebo 35.3%; odds ratio 0.93; 95% confidence interval [CI] 0.53-1.63; p = 0.80).
Read by software from the paper's abstract
Other linked trials: 9
These linked trials do not set the status.
- DELIVER-MSOngoing
Phase 4 · 2019 · Not randomised
- REGARD-PGxNo result found
Phase 4 · 2009 · Compared with glatiramer acetate
- Rehabilitation Study in MS PatientsStopped, other reason
Phase 4 · 2008 · Not randomised
- MECOMBINResult in a paper, not read yet
Phase 4 · 2003 · Placebo-controlled
- CARE-MS IIMet main goal
Phase 3 · 2007 · Compared with interferon beta-1a
- CARE-MS IMissed main goal
Phase 3 · 2007 · Compared with interferon beta-1a
Phase 2 · 2002 · Compared with interferon beta-1a
- Safety and Tolerability of Interferon-Beta-1a and Estroprogestins Association in MS PatientsResult in a paper, not read yet
Phase 2 · 2002 · Not randomised
The deciding phase and counts come from the Trial Bank’s fixed rules.
Lab evidence
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
Loading lab studies…
Loading reviews and guidelines…
History
- 2026-10-28Status changed from Being tested to Failed early
- 2026-10-27First listed as Being tested
Related hypotheses
Assembled by software from public sources and not checked by people. Each record links to its source. Report an error