MECOMBIN
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Methylprednisolone
Glucocorticoid receptor agonist
- Interferon beta-1a
Interferon alpha/beta receptor agonist
What it measured
Main measures
To estimate the effect interferon-beta-1a in combination with methylprednisolone vs interferon-beta-1a in combination with placebo on the time to onset of disability progression sustained over at least 6 months based on change from randomization in EDSS
4 years
Disability progressionImmune response
Other measures (1)
Not provided at time of registration
Who could take part
Relapsing MS · 18 to 55
Inclusion Criteria: * Informed consent * Relapsing remitting MS according to Poser criteria or McDonell criteria and naïve to therapy * Disability EDSS score of 4.0 or less at baseline * Clinical activity as defined by at least one relapse in the last year Exclusion Criteria: * Relapse in the month prior to enrolment * Treatment with immunosuppressive drugs for MS * History of major depression * Former severe reactions to corticosteroids * Pregnant women * Diabetes mellitus, and drug or alcohol dependency * Known or suspected allergy to trial products
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The primary objective of this study is to determine whether combination treatment (adding methylprednisolone to Avonex) reduces progression of disability over 4 years compared to Avonex alone. The study will also investigate whether combination therapy has any impact on the incidence of relapse and brain atrophy as measured by MRI.
Papers
Loading reviews and guidelines…
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History
Started
Jan 2003
Main results due
Nov 2008
Finished
Nov 2008
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