Being tested
BTK inhibition (B cells and microglia): reduce relapses and new lesions in relapsing MS
Trial timeline
Trial start year. Dot size reflects participants where reported. Only trials that count towards the status are shown.
relapsing MS · BTK inhibition (B cells and microglia)
Trials are running now and no controlled trial has a readable result yet.
- Trials
- 10
- Running now
- 4
- Controlled phase 2/3 trials
- 4
- People in controlled trials
- 399
Deciding trials (phase 2): 2 met, 0 did not.
Other linked trials: 8
Dose comparisons, trials against another medicine, add-on trials, phase 1 and uncontrolled studies. They are listed below but do not set the status.
Trials
- A Study of Pirtobrutinib (LY3527727 [LOXO-305]) Versus Placebo in Participants With Relapsing Multiple Sclerosisdecides the statusStopped, other reason
Phase 2 · 2024 · Placebo-controlled · MSFT-NCT06104683
Phase 2 · 2022 · Placebo-controlled · MSFT-NCT05119569
- A Phase 2 Study of Orelabrutinib in Patients With Relapsing-Remitting Multiple Sclerosisdecides the statusNo result found
Phase 2 · 2021 · Placebo-controlled · MSFT-NCT04711148
Phase 2 · 2019 · Placebo-controlled · MSFT-NCT03889639
Other linked trials: 8
These linked trials do not set the status.
- CLOU064C12306Ongoing
Phase 3 · 2025 · Compared with ocrelizumab
- FENhance 2Ongoing
Phase 3 · 2021 · Compared with teriflunomide
- FENhanceOngoing
Phase 3 · 2021 · Compared with teriflunomide
- GEMINI 1Missed main goal
Phase 3 · 2020 · Compared with teriflunomide
- GEMINI 2Missed main goal
Phase 3 · 2020 · Compared with teriflunomide
- FENerations1Ongoing
Phase 2 · 2025 · Not randomised
The deciding phase and counts come from the Trial Bank’s fixed rules.
Lab evidence
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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History
- 2026-10-28Trials: 11 → 10
- 2026-10-27First listed as Being tested
Related hypotheses
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