Interferon beta-1a
How it works: The first medicines: interferon beta and glatiramer acetate →
Avonex, Rebif
EU: Approved in the EU since 1997US: FDA approved 1996
- Molecule type
- Protein
- Mechanism (ChEMBL)
- Interferon alpha/beta receptor agonist
- Targets
- Interferon alpha/beta receptor
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Other regulatory events
- Application withdrawn · Biferonex2009-05-28 Source
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
192,383 reports in total, 102,360 marked serious.
- Multiple sclerosis relapse15,884
- Influenza like illness13,257
- Fatigue11,570
- Fall10,626
- Multiple sclerosis9,384
- Gait disturbance8,939
- Headache8,431
- Memory impairment8,000
- Pain7,760
- Injection site pain6,331
Trials
Key trials
Large trials with a reported result on their main goal.
- Glatiramer acetate, phase 3
Completed · Phase 3 · Relapsing MS · Main goal not met
- Interferon beta-1a, phase 3
Completed · Phase 3 · Relapsing MS · Equivalent
- ADVANCE
Completed · Phase 3 · Relapsing MS · Main goal met
- ORACLE MS
Completed · Phase 3 · Early (CIS/RIS) · Main goal met
- REFLEXION
Completed · Phase 3 · Early (CIS/RIS) · Main goal met
- Interferon beta-1a, phase 3
Terminated · Phase 3 · Relapsing MS · Stopped: safety
- CARE-MS II
Completed · Phase 3 · Relapsing MS · Main goal met
- CARE-MS I
Completed · Phase 3 · Relapsing MS · Main goal met
- REFORMS
Completed · Phase 3 · Relapsing MS · Main goal not met
- IMPROVE
Completed · Phase 3 · Relapsing MS · Main goal met
Running now
- DESIRE MS
Recruiting · Phase 3 · Relapsing and progressive · ongoing
- TWINS
Not yet recruiting · Phase 3 · Relapsing MS · ongoing
- INFORM
Running, not recruiting · MS (type not specified) · ongoing
- Dimethyl fumarate
Recruiting · Relapsing MS · ongoing
- STOP-I-SEP
Running, not recruiting · Phase 3 · Progressive MS · ongoing
- ABIRISK
Ongoing · Phase 4 · MS (type not specified) · ongoing
- RMaIDSM
Ongoing · Phase 3 · Relapsing MS · ongoing
Other trials (98)
Completed small trials, dose-finding studies and trials in other diseases.
- Interferon beta-1a, phase 2
Status unknown · Phase 2 · MS (type not specified) · Main goal not met
- Interferon beta-1a, phase 4
Terminated · Phase 4 · Relapsing MS · stopped_other
- Biib061, phase 2
Withdrawn · Phase 2 · Relapsing and progressive · Stopped: no effect
- INCREASE
Terminated · Phase 2 · Relapsing MS · stopped_other
- PERFECT
Completed · Relapsing MS · no_result_found
- Interferon beta-1a, phase 2 / phase 3
Completed · Phase 2 / Phase 3 · Relapsing MS · no_result_found
- MESTRE-MS
Terminated · Relapsing MS · stopped_other
- PLENO
Completed · Phase 4 · Relapsing MS · no_result_found
- Interferon beta-1a
Completed · Relapsing MS · result_in_paper_unread
- Interferon beta-1a
Completed · MS (type not specified) · no_result_found
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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