MESTRE-MS

Treatment tested

• Interferon beta-1a

  Interferon alpha/beta receptor agonist

Other measures (15)

Inclusion Criteria: * Male or female, 18 to 65 years of age (both inclusive), at the time of informed consent * Participants diagnosed with RRMS according to McDonald criteria 2010 * Participants have discontinued treatment with dimethyl fumarate (Tecfidera), teriflunomide (Aubagio), glatiramer acetate (Copaxone®), intramuscular IFNβ-1a (Avonex®), pegylated interferon (Plegridy®), subcutaneous IFNβ-1b (Betaferon®) or fingolimod (Gilenya®) within 6 months prior to Visit 1 * Currently treated with Rebif using RebiSmart 2.0, for a maximum of 6 months prior to Visit 1 * Participants have a score on the Expanded Disability Status Scale (EDSS) between 0 to 5.0 inclusive * Participants willing and able to give informed consent. Exclusion Criteria: * Participants have known planned surgical procedures at the time of the informed consent that will prevent adherence to treatment with Rebif through RebiSmart 2.0 * Participants diagnosed with primary progressive, secondary progressive, or progressive relapsing MS * pregnant or lactating, or planning to become pregnant subjects * In the opinion of the Investigator has significant renal or hepatic impairment or other significant disease (e.g., cognitive or visual impairment) that would compromise adherence and completion of the study * Reports any reason that he/she cannot complete the 1 year study * Participants have a history of hypersensitivity to natural or recombinant interferon, or any other component of the formulation * Participants who contraindicated for the treatment with subcutaneous IFNβ-1a therapy as per summary of product characteristics or currently approved specific country product information * Participants have any other factor that in the opinion of the Investigator would make the subject unsuitable for participation in this study * Participants have significant psychiatric symptoms that, in the opinion of the Investigator, would impact patient ability to comply with treatment recommendations.

This is a prospective, multicenter, open label, uncontrolled, non-interventional, single arm study to measure treatment satisfaction of relapsing remitting MS (RRMS) participants on Rebif after discontinuing initial first-line treatment.