Daclizumab
How it works: Calming and slowing immune cells →
Zinbryta
EU: WithdrawnUS: FDA approved 2016
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- Interleukin-2 receptor inhibitor
- Targets
- Interleukin-2 receptor
Approvals
Other regulatory events
- Withdrawn · Zinbryta2018-03-27 Source
Safety communications
- EMA referral · 2017-06-09
Zinbryta Source
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
1,736 reports in total, 1,697 marked serious.
- Transplant dysfunction407
- Alopecia406
- Transplant rejection406
- Acne367
- Ovarian cyst365
- Pneumonia229
- Drug ineffective188
- Condition aggravated163
- Cytomegalovirus infection162
- Pain159
Trials
Key trials
Large trials with a reported result on their main goal.
- (DECIDE)
Completed · Phase 3 · Relapsing MS · Main goal met
Other trials (13)
Completed small trials, dose-finding studies and trials in other diseases.
- SUSTAIN
Terminated · Phase 3 · Relapsing MS · stopped_other
- ZEUS
Stopped · Not a drug-phase study · Relapsing MS · stopped_other
- EXTEND
Terminated · Phase 3 · Relapsing MS · stopped_other
- OBSERVE
Completed · Phase 3 · Relapsing MS · results_posted_no_test
- SELECTED
Completed · Phase 2 · Relapsing MS · results_posted_no_test
- SELECTION
Completed · Phase 2 · Relapsing MS · Not an efficacy test
- SELECTION
Completed · Phase 2 · Relapsing MS
- SELECT
Completed · Phase 2 · Relapsing MS · Main goal met
- SELECT
Terminated · Phase 2 · Relapsing MS · stopped_other
- Daclizumab, phase 2
Completed · Phase 2 · Relapsing MS
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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