Peginterferon beta-1a
How it works: The first medicines: interferon beta and glatiramer acetate →
Plegridy
EU: Approved in the EU since 2014US: FDA approved 2014
- Molecule type
- Protein
- Mechanism (ChEMBL)
- Interferon alpha/beta receptor agonist
- Targets
- Interferon alpha/beta receptor
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
65 reports in total, 58 marked serious.
- Multiple sclerosis relapse18
- Dizziness10
- Nausea10
- Off label use7
- Anaemia6
- General physical health deterioration6
- Drug ineffective5
- Menorrhagia5
- Drug ineffective for unapproved indication4
- Therapy non-responder4
Trials
Key trials
Large trials with a reported result on their main goal.
- Dimethyl fumarate, phase 3
Terminated · Phase 3 · Relapsing MS · Stopped: safety
- ALLOW
Completed · Phase 3 · Relapsing MS · Main goal met
- ADVANCE
Completed · Phase 3 · Relapsing MS · Main goal met
Running now
- DESIRE MS
Recruiting · Phase 3 · Relapsing and progressive · ongoing
- TWINS
Not yet recruiting · Phase 3 · Relapsing MS · ongoing
- INFORM
Running, not recruiting · MS (type not specified) · ongoing
- Alemtuzumab
Running, not recruiting · Relapsing MS · ongoing
- Peginterferon beta-1a, phase 3
Running, not recruiting · Phase 3 · Relapsing MS · ongoing
- STOP-I-SEP
Running, not recruiting · Phase 3 · Progressive MS · ongoing
Other trials (12)
Completed small trials, dose-finding studies and trials in other diseases.
- PERFECT
Completed · Relapsing MS · no_result_found
- Acetaminophen, phase 4
Status unknown · Phase 4 · Relapsing and progressive · result_in_paper_unread
- PLENO
Completed · Phase 4 · Relapsing MS · no_result_found
- Interferon beta-1a
Completed · MS (type not specified) · no_result_found
- PLATINUM
Completed · Phase 4 · Relapsing MS · Main goal not met
- BRITE
Withdrawn · Phase 4 · Relapsing MS · stopped_other
- POP
Completed · Relapsing MS · no_result_found
- Interferon beta-1a, phase 1
Completed · Phase 1 · MS (type not specified) · result_in_paper_unread
- Frequency
Withdrawn · Phase 4 · Relapsing MS · stopped_other
- Dimethyl fumarate
Completed · MS (type not specified) · result_in_paper_unread
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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