Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Peginterferon beta-1a
Interferon alpha/beta receptor agonist
- Prednisone
Glucocorticoid receptor agonist
- Acetaminophen
Anandamide amidohydrolase inhibitor|Cyclooxygenase inhibitor|Vanilloid receptor opener
What it measured
Main measures
Flu-like symptoms
12 to 16 weeks
FatigueSafety
Other measures (1)
Injection site reactions
12 to 16 weeks
PainSafety
Who could take part
Relapsing and progressive · 18 and over
Inclusion Criteria: * diagnosed any form of MS (relapsing remitting, primary progressive, secondary progressive), any EDSS (expanded stability status scale) score Exclusion Criteria: * prior allergic reaction to interferon products, congestive heart failure, elevated liver enzymes
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Some of the most common side effects of the multiple sclerosis drug Plegridy (pegylated interferon beta-1a) include flu-like symptoms and injection site reactions. Physicians often advise patients to take Tylenol or aspirin prior to injection, but in this study the investigators evaluated whether using a low dose of oral steroid in combination with Tylenol reduced flu-like symptoms and injection site reactions.
Papers
Results
Rio J, Nos C, Marzo ME, Tintore M, Montalban X. Low-dose steroids reduce flu-like symptoms at the initiation of IFNbeta-1b in relapsing-remitting MS. Neurology. 1998 Jun;50(6):1910-2. doi: 10.1212/wnl.50.6.1910.Results
Brandes DW, Bigley K, Hornstein W, Cohen H, Au W, Shubin R. Alleviating flu-like symptoms with dose titration and analgesics in MS patients on intramuscular interferon beta-1a therapy: a pilot study. Curr Med Res Opin. 2007 Jul;23(7):1667-72. doi: 10.1185/030079907x210741.Results
Rio J, Nos C, Bonaventura I, Arroyo R, Genis D, Sureda B, Ara JR, Brieva L, Martin J, Saiz A, Sanchez Lopez F, Prieto JM, Roquer J, Dorado JF, Montalban X. Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial. Neurology. 2004 Aug 10;63(3):525-8. doi: 10.1212/01.wnl.0000133206.44931.25.
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History
Started
Sept 2017
Main results due
May 2020
Finished
May 2020
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