The Efficacy and Safety of Escitalopram for Depression in Multiple Sclerosis
What it found
The trial ended early for another reason (see below).
This trial finished 20 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- escitalopram oxalate antidepressant
What it measured
Main measures
Escitalopram-treated MS patients will have greater reductions in their depressive symptom scores than patients randomized to placebo
Mood and sleepAdverse events for both groups will be similar
Safety
Other measures (1)
Escitalopram-treated emotionally labile patients with MS will have a greater reduction in emotional lability scores than those randomized to placebo.
Who could take part
MS (type not specified) · 18 and over
Inclusion Criteria: * Clinical diagnosis of multiple sclerosis * Having mild to moderate depressive symptoms, with or without emotional lability * Experiencing psychological distress Exclusion Criteria: * Meeting DSM-IV diagnostic criteria for Major Depressive Disorder or another Axis 1 diagnosis * Cognitive impairment * The presence of an unstable medical illness that might preclude completion of the study -
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Emotionally labile, depressed participants with multiple sclerosis treated with escitalopram will have a greater reduction in emotional lability scores and in their psychological distress scores than those who are randomized to receive placebo.
Loading reviews and guidelines…
Related trials
- QSIT
Phase 1 / Phase 2 · Enrolling by invitation
Still running
- DRI_2020/03
Phase 3 · Not yet recruiting
Still running
- Ketamine for MS Fatigue
Early phase 1 · Completed
Result in a paper, not read yet
- INKLING-MS
Phase 2 · Running, not recruiting
Still running
- Ketamine for Treatment of MS Fatigue
Phase 1 / Phase 2 · Completed
Results posted, no main test reported
- Treatment of Pendular Nystagmus in OPT
Phase 4 · Completed
Result in a paper, not read yet
History
Started
Nov 2004
Finished
Oct 2006
Assembled by software from public sources and not checked by people. Each record links to its source. Report an error