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Studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of a hypothesis.
2,710 lab studies
2,710 lab studies match
furapyrrodole · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
In mice with EAE, a model of MS, a compound called furapyrrodole given after disease peak improved motor function and boosted nerve cell and myelin repair.
nor-NOHA · Frontiers in immunology · 2026
In mice with EAE, daily oral nor-NOHA, which blocks the ARG1 enzyme, was given before symptoms and was linked to lower clinical scores and less spinal cord damage.
Teriflunomide · Pharmaceutics · 2026
In mice with EAE, teriflunomide given in carboxymethylcellulose eased disease, while the same drug mixed in sweetened milk did not, showing vehicle choice matters.
Liproxstatin-1 (Lip-1) · Brain, behavior, and immunity · 2026
In mice with EAE, an early dose of the ferroptosis inhibitor Liproxstatin-1 reduced disease severity and protected brain white matter, as shown by high-field MRI.
IRF8 knockout · Neuromolecular medicine · 2026
In mice with EAE, a model of MS, removing the IRF8 gene prevented disease and reduced inflammatory signals in the spinal cord.
MOG 35-55 loaded AMPs · Biomaterials science · 2026
In mice with EAE, a model of MS, B cells coated with antigen-loaded acetalated dextran microparticles and transferred into the animals significantly lowered clinical disease scores.
SERPINA3(k), SERPINA3D2 mutant, anti-SERPINA3(k) antibodies · Nature immunology · 2026
In mice with EAE, a soluble SERPINA3 protein that binds the SIRPα receptor reduced inflammation and disease, while a mutant version avoided harmful effects on blood vessels and heart cells.
Tcf7 · Cell reports · 2026
In mice with EAE, removing the TCF1 gene from interleukin 17 producing immune cells made them lose their protective traits and worsened disease.
beta-cyclodextrin · Toxicology communications · 2026
In mice with EAE, a model of multiple sclerosis, adding beta-cyclodextrin to chow reduced deaths linked to PFOS exposure and lowered PFOS levels in the blood.
ketogenic diet (KD), intermittent ketone ester injections (iKE) · Multiple sclerosis and related disorders · 2026
In mice with cuprizone-induced demyelination, a ketogenic diet or ketone ester injections raised myelin protein staining during early recovery but did not improve behavior.
TNFα inhibition · Journal of immunology (Baltimore, Md. : 1950) · 2026
In mice with multiple sclerosis like disease lacking IFNγ and IL-17A, blocking TNFα reduced inflammation that spread to the brain, while removing these cytokines did not stop disease.
CYBB overexpression · Gene · 2026
In mice with EAE, an MS-like model, boosting the CYBB gene reduced inflammation, oxidative stress and pyroptosis, and eased disease symptoms.
fingolimod · Frontiers in neurology · 2026
In mice with EAE, a multi-scan MRI panel tracked spinal cord damage and clinical paralysis, and fingolimod treatment rescued these deficits.
CCR2 deficiency · Neurobiology of disease · 2026
In mice with EAE, a model of MS, removing the CCR2 receptor reduced immune cell entry into the spinal cord and nearly prevented disease.
IgA knockout (KO) mice · Cells · 2026
In mice infected with Theiler's virus, a model of MS, removing IgA made neurological signs, inflammation and nerve damage worse.
kamuvudine-9 (K-9) · Science translational medicine · 2026
In mice with EAE, the drug kamuvudine-9 prevented worsening, reversed existing paralysis and vision loss, and protected spinal cord myelin and nerve fibers.
alcoholic frankincense extract · Avicenna journal of phytomedicine · 2026
In mice with EAE, an oral frankincense extract reduced inflammatory signals and oxidative stress, and protected myelin in the brain.
minocycline · Frontiers in immunology · 2026
In mice with EAE, minocycline given at disease peak eased symptoms by limiting harmful reactive oxygen and nitric oxide production in CD4 immune cells, independent of Nrf2.
wtTIDM · NeuroImmune pharmacology and therapeutics · 2026
In cuprizone-treated mice with demyelination, intranasal wtTIDM peptide that selectively inhibits TLR2 increased oligodendrocyte maturation and remyelination in the corpus callosum.
Huangqi Guizhi Wuwu Decoction · Fitoterapia · 2026
In mice with EAE, a traditional Chinese herbal decoction reduced disease severity and nerve damage by boosting cellular clearance of damaged mitochondria and calming inflammatory microglia.
Moringa oleifera leaf extract (MOLE) · Tissue & cell · 2026
In rats given cuprizone to damage myelin, Moringa leaf extract improved movement tests and reduced oxidative stress, inflammation, and nerve tissue damage.
TRANQUIL · Brain research · 2026
Engineered bacteria producing indole partially reduced clinical severity and CNS inflammation in mice with EAE, a model of MS.
upadacitinib (UPA), MCL1 inhibition · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Using patient blood cells and mice with EAE, blocking JAK1 with upadacitinib restored immune balance and reduced disease, suggesting a possible therapy for optic neuritis.
4-aminobenzoic acid hydrazide · NeuroImage · 2026
In mice with EAE, a PET and MRI scan method tracked myeloperoxidase enzyme activity in inflamed brain and spinal cord, and blocking the enzyme after symptoms began did not quickly lower tissue acrolein.
Fasudil (FSD) · Metabolic brain disease · 2026
In mice given cuprizone to cause demyelination, the drug fasudil pushed astrocytes toward a repair-supporting state, reducing inflammation and helping myelin recover.