Eculizumab
How it works: Medicines for NMOSD and MOGAD →
Soliris
EU: Approved in the EU since 2007US: FDA approved 2007
- Other names
- eculizumab-aagh, eculizumab-aeeb
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- Complement C5 inhibitor
- Targets
- Complement C5
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
54,452 reports in total, 32,708 marked serious.
- Fatigue5,912
- Off label use4,834
- Haemoglobin decreased3,939
- Headache3,491
- Death2,773
- Pyrexia2,438
- Dyspnoea2,196
- Asthenia2,045
- Nausea2,001
- Drug ineffective1,969
Trials
Running now
- Rituximab Versus Ravulizumab, Inebilizumab, Satralizumab, and Eculizum
Recruiting · Phase 4 · NMOSD · Still running
- Therapy in the Acute Phase of NMOSD: A Multicenter Prospective Real-Wo
Recruiting · Phase 4 · NMOSD · Still running
- Eculizumab For the Acute Attack of Neuromyelitis Optica Spectrum Disor
Running, not recruiting · Phase 2 · NMOSD · Still running
- Efficacy, Safety, PK, PD, and ADA of Eculizumab in Chinese Adults With
Running, not recruiting · Phase 3 · NMOSD · Still running
Other trials (5)
Completed small trials, dose-finding studies and trials in other diseases.
- Eculizumab For Acute Attack of Neuromyelitis Optica Spectrum Disorder
Withdrawn · Phase 2 · NMOSD · Stopped
- A Study of the Safety and Activity of Eculizumab in Pediatric Particip
Terminated · Phase 2 / Phase 3 · NMOSD · Stopped
- An Open Label Extension Trial of Eculizumab in Relapsing NMO Patients
Completed · Phase 3 · NMOSD · Results posted, not judged
- A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive
Terminated · Phase 3 · NMOSD · Stopped
- An Open Label Study of the Effects of Eculizumab in Neuromyelitis Opti
Completed · Phase 1 / Phase 2 · NMOSD · Met its main goal
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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