Ravulizumab
How it works: Medicines for NMOSD and MOGAD →
Ultomiris
EU: Approved in the EU since 2019US: FDA approved 2018
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- Complement C5 inhibitor
- Targets
- Complement C5
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
14,204 reports in total, 8,146 marked serious.
- Fatigue1,819
- Asthenia925
- Drug ineffective775
- Headache773
- Death677
- Off label use584
- Dyspnoea548
- Muscular weakness532
- Myasthenia gravis512
- Malaise483
Trials
Key trials
Large trials with a reported result on their main goal.
- An Efficacy and Safety Study of Ravulizumab in Adult Participants With
Completed · Phase 3 · NMOSD · Met its main goal
Running now
- Rituximab Versus Ravulizumab, Inebilizumab, Satralizumab, and Eculizum
Recruiting · Phase 4 · NMOSD · Still running
- Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenici
Recruiting · Phase 3 · NMOSD · Still running
- Study of Ultomiris® (Ravulizumab) Safety in Pregnancy
Recruiting · NMOSD · Still running
- Study of the Clinical and Radiological Impact of Ravulizumab in People
Recruiting · NMOSD · Still running
- Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants
Running, not recruiting · Phase 2 / Phase 3 · NMOSD · Still running
- Clinical study testing the efficacy and safety of Ravulizumab in pedia
Running, not recruiting · Phase 2 / Phase 3 · NMOSD · Still running
- Clinical study testing the efficacy and safety of Ravulizumab in pedia
Ongoing · Phase 2 / Phase 3 · NMOSD
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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