Satralizumab
How it works: Medicines for NMOSD and MOGAD →
Enspryng
EU: Approved in the EU since 2021US: FDA approved 2020
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- IL6Ralpha/GP130 antagonist
- Targets
- IL6Ralpha/GP130
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
322 reports in total, 301 marked serious.
- Neuromyelitis optica spectrum disorder80
- Off label use60
- Urinary tract infection34
- Muscular weakness22
- Hypoaesthesia20
- Pneumonia20
- Infection19
- Fatigue18
- Optic neuritis18
- Covid-1914
Trials
Key trials
Large trials with a reported result on their main goal.
- Efficacy and Safety Study of Satralizumab (SA237) as Monotherapy to Tr
Completed · Phase 3 · NMOSD · Met its main goal
- Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to
Completed · Phase 3 · NMOSD · Met its main goal
Running now
- Rituximab Versus Ravulizumab, Inebilizumab, Satralizumab, and Eculizum
Recruiting · Phase 4 · NMOSD · Still running
- A Multicenter Prospective Real-World Effectiveness and Safety of Satra
Recruiting · NMOSD · Still running
- A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability,
Recruiting · Phase 3 · NMOSD · Still running
- HANDLE-a Real World Study on Satralizumab in NMOSD
Recruiting · NMOSD · Still running
- A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharma
Running, not recruiting · Phase 3 · MOGAD · Still running
Other trials (2)
Completed small trials, dose-finding studies and trials in other diseases.
- A Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satrali
Terminated · Phase 4 · NMOSD · Stopped
- A Study to Evaluate the Safety and Efficacy of Satralizumab in Partici
Completed · Phase 3 · NMOSD · Results posted, not judged
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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