Diroximel fumarate
How it works: Calming and slowing immune cells →
Vumerity
EU: Approved in the EU since 2021US: FDA approved 2019
- Molecule type
- Small molecule
- Mechanism (ChEMBL)
- Kelch-like ECH-associated protein 1 inhibitor
- Targets
- Kelch-like ECH-associated protein 1
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
11,848 reports in total, 4,590 marked serious.
- Flushing1,611
- Multiple sclerosis1,099
- Multiple sclerosis relapse973
- Diarrhoea873
- Product dose omission issue820
- Fatigue781
- Nausea753
- Headache619
- Pruritus590
- Memory impairment566
Trials
Key trials
Large trials with a reported result on their main goal.
- Diroximel fumarate, phase 3
Completed · Phase 3 · Relapsing MS · Main goal met
Running now
- VOYAGE
Not yet recruiting · Phase 3 · Relapsing MS · ongoing
- DESIRE MS
Recruiting · Phase 3 · Relapsing and progressive · ongoing
- TWINS
Not yet recruiting · Phase 3 · Relapsing MS · ongoing
- Dimethyl fumarate
Running, not recruiting · MS (type not specified) · ongoing
- Dimethyl fumarate
Recruiting · Relapsing MS · ongoing
- Dimethyl fumarate
Running, not recruiting · Relapsing MS · ongoing
- Alemtuzumab
Running, not recruiting · Relapsing MS · ongoing
Other trials (7)
Completed small trials, dose-finding studies and trials in other diseases.
- FUSION
Completed · Phase 2 · Relapsing and progressive · result_in_paper_unread
- Diroximel fumarate
Terminated · Relapsing and progressive · stopped_other
- Diroximel fumarate, phase 3
Completed · Phase 3 · Relapsing MS · results_posted_no_test
- Diroximel fumarate
Terminated · Relapsing and progressive · stopped_other
- STATURE
Status unknown · MS (type not specified) · no_result_found
- Diroximel fumarate, phase 3
Completed · Phase 3 · Relapsing MS · results_posted_no_test
- Diroximel fumarate, phase 1
Completed · Phase 1 · MS (type not specified) · no_result_found
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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