Laquinimod
How it works: Calming and slowing immune cells →
EU: RefusedUS: Not FDA approved
- Molecule type
- Small molecule
Approvals
- EU/EEANerventra · Refused2014-08-19 Source
Other regulatory events
- Refused · Nerventra2014-08-19 Source
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
13 reports in total, 10 marked serious.
- Psychiatric decompensation5
- Oral herpes2
- Affective disorder1
- Agranulocytosis1
- Altered state of consciousness1
- Back pain1
- C-reactive protein abnormal1
- Chest discomfort1
- Completed suicide1
- Condition aggravated1
Trials
Key trials
Large trials with a reported result on their main goal.
- CONCERTO
Completed · Phase 3 · Relapsing MS · Main goal not met
- BRAVO
Completed · Phase 3 · Relapsing MS · Main goal not met
- ALLEGRO
Completed · Phase 3 · Relapsing MS · Main goal met
Other trials (7)
Completed small trials, dose-finding studies and trials in other diseases.
- ARPEGGIO
Completed · Phase 2 · Progressive MS · Main goal not met
- LIBRETTO
Withdrawn · Phase 3 · Relapsing MS · stopped_other
- -
Terminated · Phase 3 · Relapsing MS · stopped_other
- -
Terminated · Phase 3 · Relapsing MS · stopped_other
- Allegro
Terminated · Phase 3 · Relapsing MS · stopped_other
- Laquinimod, phase 2
Terminated · Phase 2 · Relapsing MS · stopped_other
- Laquinimod, phase 2
Completed · Phase 2 · Relapsing MS · result_in_paper_unread
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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