Teriflunomide
How it works: Calming and slowing immune cells →
Aubagio
EU: Approved in the EU since 2013US: FDA approved 2012
- Molecule type
- Small molecule
- Mechanism (ChEMBL)
- Dihydroorotate dehydrogenase inhibitor
- Targets
- Dihydroorotate dehydrogenase (quinone), mitochondrial
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
44,980 reports in total, 19,534 marked serious.
- Alopecia6,076
- Multiple sclerosis relapse5,230
- Fatigue4,765
- Diarrhoea4,759
- Fall3,342
- Hypoaesthesia3,172
- Headache3,005
- Drug ineffective2,821
- Paraesthesia2,814
- Nausea2,750
Trials
Key trials
Large trials with a reported result on their main goal.
- TERIS
Completed · Phase 3 · Early (CIS/RIS) · Main goal met
- TERIKIDS
Completed · Phase 3 · Relapsing MS · Main goal not met
- TERACLES
Terminated · Phase 3 · Relapsing MS · Stopped: safety
- TENERE
Completed · Phase 3 · Relapsing MS · Main goal not met
- TOWER
Completed · Phase 3 · Relapsing MS · Main goal met
- TOPIC
Completed · Phase 3 · Early (CIS/RIS) · Main goal met
- Teriflunomide, phase 3
Completed · Phase 3 · Relapsing MS · Not an efficacy test
- TEMSO
Completed · Phase 3 · Relapsing and progressive · Main goal met
Running now
- DESIRE MS
Recruiting · Phase 3 · Relapsing and progressive · ongoing
- TWINS
Not yet recruiting · Phase 3 · Relapsing MS · ongoing
- FENhance 2
Running, not recruiting · Phase 3 · Relapsing MS · ongoing
- FENhance
Running, not recruiting · Phase 3 · Relapsing MS · ongoing
- STOP-I-SEP
Running, not recruiting · Phase 3 · Progressive MS · ongoing
- TERIPET
Running, not recruiting · Phase 4 · Progressive MS · ongoing
Other trials (29)
Completed small trials, dose-finding studies and trials in other diseases.
- TDM-MS
Status unknown · Phase 4 · MS (type not specified) · no_result_found
- TERIFIN
Completed · Phase 4 · MS (type not specified) · no_result_found
- Teriflunomide, phase 4
Completed · Phase 4 · MS (type not specified) · no_result_found
- STATURE
Status unknown · MS (type not specified) · no_result_found
- TERI-PK
Completed · Phase 4 · Relapsing MS · result_in_paper_unread
- Teriflunomide, phase 4
Completed · Phase 4 · Relapsing MS · result_in_paper_unread
- SAFE
Completed · Phase 4 · Relapsing MS · no_result_found
- Dimethyl fumarate
Completed · MS (type not specified) · result_in_paper_unread
- Teriflunomide
Completed · Relapsing MS · no_result_found
- nd
Terminated · Phase 4 · Relapsing MS · stopped_other
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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