Study to evaluate the efficacy of cetirizine in the treatment of Flu-l
Flu-like syndrome Inhibition Giving anti-histaminic Therapy. Randomized cross-over, single-center, randomized, placebo-controlled, double-blind study to evaluate the efficacy of cetirizine on Flu-like syndrome (FLS) in patients with multiple sclerosis treated with interferoneβ.
What it found
The main measure did not show a significant benefit.
“The differences between cetirizine and placebo in the intensity of FLS were not statistically significant: total mean VAS scores at 4 hours from IFNβ injection were 3.57 and 3.42 for cetirizine and placebo, respectively (difference -0.15; 95% confidence interval: from -0.74 to 0.44; p = 0.6029).”Read by software from the paper's abstract
| Group | n | Value |
|---|---|---|
| cetirizine | 3.57 | |
| placebo | 3.42 |
mean difference -0.15 (95% CI -0.74–0.44)
p = 0.6029
Read by software from the paper's abstract
What was tested
Treatment tested
- Cetirizine
What it measured
Main measures
See objectives.
Other measures (1)
See objectives.
Who could take part
Relapsing MS
Show the full criteria
Inclusion criteria
Inclusion: • Individuals of both sexes. Exclusion: • Subjects (male or female) of childbearing potential who are not using contraceptives
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
To evaluate the effectiveness of the administration of cetirizine 10 mg on the improvement of the symptoms of FLS.
Papers
Results
Management of flu-like syndrome with cetirizine in patients with relapsing-remitting multiple sclerosis during therapy with interferon beta: Results of a randomized, cross-over, placebo-controlled pilot study.PLoS One · 2017
The differences between cetirizine and placebo in the intensity of FLS were not statistically significant: total mean VAS scores at 4 hours from IFNβ injection were 3.57 and 3.42 for cetirizine and placebo, respectively (difference -0.15; 95% confidence interval: from -0.74 to 0.44; p = 0.6029).
Read by software from the paper's abstract
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History
Started
Jun 2013