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Cognitive impairment and functional reorganization in multiple sclerosis: The role of GABA and glutamate

Status unknownPhase 4MS (type not specified)2017-002636-16

What it found

No results found

We found no results in the registry or in papers.

What was tested

Treatment tested

  • [11C]flumazenil

What it measured

Main measures

  • The primary end point of this study is a significant difference in levels of GABA, glutamate and GABAA receptors between healthy controls and cognitively preserved and impaired MS patients. More specifically, we expect differences in the levels of GABA and glutamate in the thalamus and hippocampus and levels of GABAA receptors in the grey matter between the study groups.

    Thinking and memory

Other measures (1)

  • A secondary end point is a significant correlation between the characteristics of the GABAergic and glutamatergic system as described above and levels of functional activation. More specfically, we investigate hippocampal activation during a memory task (using fMRI) and expect the level of the BOLD-signal to be related to the levels of GABA, glutamate and GABAA receptors.

    Thinking and memoryNerve conduction tests

Who could take part

MS (type not specified)

Show the full criteria

Inclusion criteria

Inclusion: To participate in the MRI part of the study: Exclusion: For the MRI-part of the study:

Exclusion criteria

Not separately supplied in the registry.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

The main objective of this study is to investigate if the occurrence of cognitive impairment and functional reorganization in MS can be explained by changes in GABA and glutamate concentration and GABAA receptor binding. The levels of GABA and glutamate will be measured with Magnetic Resonance Spectroscopy and the binding of GABAA receptors will be assessed with Positron Emission Tomography.

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History

  1. Status changed from Ongoing to Status unknown
  2. Result signal changed from Ongoing to Status unknown

  1. Started

    Aug 2017

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