TREating FAtigue in Multiple Sclerosis: Aerobic training
A randomized clinical trial looking at disabling fatigue in multiple sclerosis occurs frequently. How should it be treated? A randomized clinical trial
What it found
A paper reports the results; we have not read it yet. See Papers below.
What it measured
Main measures
1. Fatigue: checklist individual strength (CIS) subscale fatigue 2. Participation: impact on participation and autonomy (IPA)
FatiguePhysical function
Other measures (1)
1. Medical outcome study short form 36 (SF36) 2. Rehabilitation activities profile (RAP) 3. Fatigue severity scale (FSS) 4. Checklist individual strength (CIS) subscales motivation, concentration, activity modified fatigue impact scale (MFIS)
FatiguePhysical functionQuality of life (reported by participants)
Who could take part
Early (CIS/RIS) · 18 to 70
Show the full criteria
Inclusion criteria
Inclusion: 1. Diagnosis of MS according to the criteria of McDonald 2. Able to walk with no more than one unilateral walking aid i.e. able to walk with no more than one unilateral walking aid 3. Suffering from fatigue, defined as a score higher than 35 on the subscale fatigue of the Checklist Individual Strength (CIS) 4. Age between 18-70 years Exclusion: 1. Patients using in the last three months prior to inclusion Amantadine, Modafinil, Ritalin or Pemoline for their fatigue 2. Major depression
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Not provided at time of registration
Papers
Results
Brain-derived neurotrophic factor, neurofilament light and glial fibrillary acidic protein do not change in response to aerobic training in people with MS-related fatigue - a secondary analysis of a randomized controlled trial.Mult Scler Relat Disord · 2023
Results
Does aerobic training alleviate fatigue and improve societal participation in patients with multiple sclerosis? A randomized controlled trial.Mult Scler · 2017
Results
Fatigue in patients with multiple sclerosis: is it related to pro- and anti-inflammatory cytokines?Dis Markers · 2015
Results
The effectiveness of aerobic training, cognitive behavioural therapy, and energy conservation management in treating MS-related fatigue: the design of the TREFAMS-ACE programme.Trials · 2013
Results
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History
Started
Sept 2011
Finished
Apr 2014