TREating FAtigue in Multiple Sclerosis: Energy conservation management
Disabling fatigue in multiple sclerosis occurs frequently: how should it be treated? A randomized clinical trial
What it found
A paper reports the results; we have not read it yet. See Papers below.
What it measured
Main measures
1. Fatigue: Checklist Individual Strength (CIS) subscale fatigue 2. Participation: Impact on Participation and Autonomy (IPA) The 6 time points are: week-1, week 0, week 8, week 16, week 26 and week 52
FatiguePhysical function
Other measures (1)
1. Medical Outcome study Short Form 36 (SF36) 2. Rehabilitation Activities Profile (RAP) 3. Fatigue Severity Scale (FSS) 4. Checklist Individual Strength (CIS) subscales motivation, concentration, activity 5. Modified Fatigue Impact Scale (MFIS) The 6 time points are: week -1, week 0, week 8, week 16, week 26 and week 52
FatiguePhysical functionQuality of life (reported by participants)
Who could take part
Early (CIS/RIS) · 18 to 70
Show the full criteria
Inclusion criteria
Inclusion: Ambulatory multiple sclerosis (MS) patients fulfulling the following enrollment criteria: 1. Age between 18-70 years 2. Diagnosis of MS according to the criteria of McDonald 3. Able to walk with no more than one unilateral walking aid i.e. able to walk with no more than one unilateral walking aid 4. Suffering from fatigue, defined as a score higher than 35 on the subscale fatigue of the Checklist Individual Strength (CIS) Exclusion: 1. Patients using in the last three months prior to inclusion amantadine, modafinil, Ritalin® or pemoline for their fatigue 2. Major depression
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Not provided at time of registration
Papers
Results
Fatigue in patients with multiple sclerosis: is it related to pro- and anti-inflammatory cytokines?Dis Markers · 2015
Results
The effectiveness of aerobic training, cognitive behavioural therapy, and energy conservation management in treating MS-related fatigue: the design of the TREFAMS-ACE programme.Trials · 2013
Results
results
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History
Started
Sept 2011
Finished
Apr 2014