Restoration of Walking in Multiple Sclerosis Using Treadmill Training.
Pilot Study on Gait & Motor Function in MS Using BWS Treadmill Training
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Body-weight supported treadmill
- Lokomat
What it measured
Main measures
Mean changes and variances in ambulation, motor, fatigue and quality of life
Baseline, cross-over, study endpoint
Disability progressionFatigueWalking and mobilityQuality of life (reported by participants)
Who could take part
MS (type not specified) · 18 and over · EDSS 4 to 6.5
Show the full criteria
Inclusion criteria
* Clinical diagnosis of MS by McDonald criteria. EDSS level between 4-6.5.
Exclusion criteria
* Cardiovascular: recent MI \< 4 wk, uncontrolled HTN >190/110 mmHg, Uncontrolled diabetes (blood glucose 2X above the upper limit of normal or non-fasting blood drain). * Symptomatic fall in blood pressure (>30mm Hg), when upright in the body support apparatus, despite medical therapy. * Circulatory problems, history of vascular claudication or pitting edema. * Cognitive impairment MMSE \< 21. * Body weight over 150 kg (structural limits of the Lokomat). * Lower extremity injuries that limit range of motion or function. * Joint problems (hip or leg) that limit range of motion or cause pain with movement despite treatment. * Unstable fractures. * Pressure sores with any skin breakdown in areas in contact with the body harness or DGO apparatus. * Chronic and ongoing alcohol or drug abuse. * Pre-morbid, ongoing depression or psychosis.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The primary purpose of this study is to collect preliminary and pilot data to begin to determine whether the use of body weight support treadmill therapy (BWSTT) with and without driven-gait-orthotics (DGO), results in improved motor recovery and ambulation MS patients with gait impairment
Papers
Results
Lo AC, Triche EW. Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil Neural Repair. 2008 Nov-Dec;22(6):661-71. doi: 10.1177/1545968308318473.Results
Wier LM, Hatcher MS, Triche EW, Lo AC. Effect of robot-assisted versus conventional body-weight-supported treadmill training on quality of life for people with multiple sclerosis. J Rehabil Res Dev. 2011;48(4):483-92. doi: 10.1682/jrrd.2010.03.0035.
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History
Started
Sept 2004
Main results due
Sept 2007
Finished
Sept 2007