TCV -01-002: T-Cell Vaccination in the Treatment of Probable Multiple
T-Cell Vaccination in the Treatment of Probable Multiple Sclerosis
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- T cell vaccination
What it measured
Main measures
The rate of progression to definite MS (second attack) during the study
RelapsesTime to progression to definite MS (second attack)
Disability progressionRelapses
Other measures (3)
Change in the count of new gadolinium (GD) enhancing lesions from two baseline (B) MRIs to the final (F) MRIs
MRI lesionsChange in total volume of new GD enhancing lesions from two baseline MRIs (B) to the final MRIs (F)
MRI lesionsThe change in neurological disability as measured by the Expanded Disability Status Scale (EDSS)
Disability progression
Who could take part
MS (type not specified) · 15 to 50
Show the full criteria
Inclusion criteria
* Ages 15-50 * Three months within the acute onset of neurological symptoms suggestive of multiple sclerosis * Diagnosis of clinically probable MS (CPMS) C3: 1 attack with at least 1 clinical manifestation in addition to positive brain MRI as defined in the protocol, signifying paraclinical evidence (Poser criteria 1983). * Positive Brain MRI: at least 4 focal lesions involving the white matter of 3 lesions if one is periventricular > 3mm diameter, each * Negative pregnancy test and use of effective contraceptives for female patients who are sexually active. * Signed written informed consent.
Exclusion criteria
* Blood tests suggestive of other autoimmune diseases * Known allergic reaction to MRI contrast media. * A clear regression of the neurological symptoms after the first attack that excludes a primary progressive course. * Corticosteroid treatment in the previous 4 weeks. * Previous treatment with immunosuppressive medications such as cyclophosphamide, azathioprine, methotrexate, mitoxantrone, or cyclosporine. * Previous treatment with interferon beta 1a or 1b copolymer-1 IVIg, plasmapheresis.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
In the present study, we, the investigators at Sheba Medical Center, intend to evaluate T cell vaccination (TCV) in patients with probable multiple sclerosis (MS) within up to 3 months after the first clinical attack. It is of the utmost importance to evaluate the treatment effects at the onset of disease, i.e. in patients with probable MS, in order to evaluate whether early treatment can prevent the second attack (conversion to definite MS). Moreover, at disease onset, the immunological process of epitope spreading associated with the exposure of the immune system to myelin antigens is still limited. With additional attacks, increased recognition of new self-determinants of encephalitogenic peptides presented to the immune system during the inflammatory process occurs, and enhances further disease activity. The aim of the early TCV treatment approach is to stop this process as early as possible, during the onset of the disease, thus preventing additional attacks and disease progression. We will evaluate the effect of TCV on clinical, immunological and magnetic resonance imaging (MRI) parameters in patients with probable MS.
Papers
Loading reviews and guidelines…
History
Started
May 2002
Finished
Dec 2006